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    Ildr2 immunoglobulin-like domain containing receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685277, updated on 9-Dec-2024

    Summary

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    Symbol
    Ildr2provided by RGD
    Full Name
    immunoglobulin-like domain containing receptor 2provided by RGD
    Primary source
    RGD:1596420
    See related
    EnsemblRapid:ENSRNOG00000025151 AllianceGenome:RGD:1596420
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in negative regulation of T cell activation; pancreas development; and regulation of RNA splicing. Predicted to act upstream of or within several processes, including homeostasis of number of cells within a tissue; insulin secretion; and response to glucose. Predicted to be located in tight junction. Predicted to be active in membrane. Orthologous to human ILDR2 (immunoglobulin like domain containing receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 71.1), Kidney (RPKM 38.8) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ildr2 in Genome Data Viewer
    Location:
    13q23
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (81051723..81113590)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (78518770..78580627)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (84474191..84532347)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene glycoprotein A33 Neighboring gene cold shock domain-containing protein E1-like Neighboring gene maelstrom spermatogenic transposon silencer Neighboring gene uncharacterized LOC120096307 Neighboring gene uncharacterized LOC120096308 Neighboring gene transcriptional adaptor 1 Neighboring gene pogo transposable element derived with KRAB domain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice. Dokmanovic-Chouinard M, et al. PLoS Genet, 2008 Jul 25. PMID 18654634, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of cells within a tissue ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pancreas development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pancreas development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to glucose ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    immunoglobulin-like domain-containing receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      81051723..81113590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769713.3 → XP_008767935.2  immunoglobulin-like domain-containing receptor 2 isoform X1

      UniProtKB/TrEMBL
      D3ZGJ1
      Related
      ENSRNOP00000036628.5, ENSRNOT00000031367.7
      Conserved Domains (2) summary
      pfam05624
      Location:186 → 212
      LSR; Lipolysis stimulated receptor (LSR)
      cl11960
      Location:36 → 166
      Ig; Immunoglobulin domain

    2. XM_017598996.3 → XP_017454485.1  immunoglobulin-like domain-containing receptor 2 isoform X2

      UniProtKB/TrEMBL
      D3ZGJ1
      Conserved Domains (2) summary
      pfam05624
      Location:170 → 196
      LSR; Lipolysis stimulated receptor (LSR)
      cl11960
      Location:18 → 129
      Ig; Immunoglobulin domain

    3. XM_008769716.4 → XP_008767938.1  immunoglobulin-like domain-containing receptor 2 isoform X2

      See identical proteins and their annotated locations for XP_008767938.1

      UniProtKB/TrEMBL
      D3ZGJ1
      Conserved Domains (2) summary
      pfam05624
      Location:170 → 196
      LSR; Lipolysis stimulated receptor (LSR)
      cl11960
      Location:18 → 129
      Ig; Immunoglobulin domain

    4. XM_017598997.3 → XP_017454486.1  immunoglobulin-like domain-containing receptor 2 isoform X2

      UniProtKB/TrEMBL
      D3ZGJ1
      Conserved Domains (2) summary
      pfam05624
      Location:170 → 196
      LSR; Lipolysis stimulated receptor (LSR)
      cl11960
      Location:18 → 129
      Ig; Immunoglobulin domain

    5. XM_039091405.1 → XP_038947333.1  immunoglobulin-like domain-containing receptor 2 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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