Mphosph8 M-phase phosphoprotein 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Mphosph8provided by RGD
Full Name: M-phase phosphoprotein 8provided by RGD
Primary source: RGD:1305133
See related: EnsemblRapid:ENSRNOG00000061152 AllianceGenome:RGD:1305133
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ab2-008; RGD1305133; AABR07018038.3
Summary: Predicted to enable chromatin binding activity; histone reader activity; and methylated histone binding activity. Predicted to be involved in negative regulation of gene expression via chromosomal CpG island methylation; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; and positive regulation of DNA methylation-dependent heterochromatin formation. Predicted to be located in several cellular components, including cytosol; heterochromatin; and nuclear lumen. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to human MPHOSPH8 (M-phase phosphoprotein 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 183.2), Uterus (RPKM 134.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (34916169..34944038)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (30800546..30828415)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (36918843..36946712)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that MPP8 could have a role for silencing genes that are associated with differentiation of the testis and the mesoderm by interacting with epigenetic repressors modules such as the PRC1 complex.
Title: Physical interaction between MPP8 and PRC1 complex and its implication for regulation of spermatogenesis.

Submit: New GeneRIF Correction

General gene information

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Markers

RH140711 (e-PCR)
- UniSTS:222777

AI235955 (e-PCR)
- UniSTS:250581

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone reader activity	ISO Inferred from Sequence Orthology more info
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables methylated histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in constitutive heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in constitutive heterochromatin formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression via chromosomal CpG island methylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression via chromosomal CpG island methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
involved_in transposable element silencing by heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in transposable element silencing by heterochromatin formation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in heterochromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in heterochromatin	ISO Inferred from Sequence Orthology more info
located_in heterochromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
part_of nucleosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: M-phase phosphoprotein 8

Names: M-phase phosphoprotein, mpp8

NP_001017375.2

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017375.2 → NP_001017375.2 M-phase phosphoprotein 8

See identical proteins and their annotated locations for NP_001017375.2

Status: VALIDATED

Source sequence(s)

BC099116, BP474651, CB700328

UniProtKB/Swiss-Prot

G3V8T1, Q4KLM1

Related

ENSRNOP00000028145.4, ENSRNOT00000028145.9

Conserved Domains (4) summary

smart00298
Location:58 → 109

CHROMO; Chromatin organization modifier domain

cd00204
Location:586 → 710

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:597 → 686

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:594 → 622

ANK; ANK repeat [structural motif]