Glmn glomulin, FKBP associated protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Glmnprovided by RGD
Official Full Name: glomulin, FKBP associated proteinprovided by RGD
Primary source: RGD:1588600
See related: EnsemblRapid:ENSRNOG00000002054 AllianceGenome:RGD:1588600
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable hepatocyte growth factor receptor binding activity; ubiquitin protein ligase binding activity; and ubiquitin-protein transferase inhibitor activity. Predicted to be involved in several processes, including negative regulation of T cell proliferation; regulation of gene expression; and vasculogenesis. Predicted to act upstream of or within several processes, including neural tube closure; positive regulation of interleukin-2 production; and regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex; Cul3-RING ubiquitin ligase complex; and Cul4A-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in arteriovenous malformation; glomangioma; and glomus tumor. Orthologous to human GLMN (glomulin, FKBP associated protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 72.0), Thymus (RPKM 57.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (2332052..2375366)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (2187144..2231295)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (3204390..3247703)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D14Got3 (e-PCR)
- UniSTS:111641

RH133631 (e-PCR)
- UniSTS:216914

BE102235 (e-PCR)
- UniSTS:244104

RH131951 (e-PCR)
- UniSTS:215234

BF388461 (e-PCR)
- UniSTS:244952

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hepatocyte growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within circulatory system development	ISO Inferred from Sequence Orthology more info
involved_in epigenetic regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in vasculogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul3-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul4A-RING E3 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of cullin-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glomulin

Names: FKBP associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.