Mcu mitochondrial calcium uniporter [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mcuprovided by RGD
Official Full Name: mitochondrial calcium uniporterprovided by RGD
Primary source: RGD:1589771
See related: EnsemblRapid:ENSRNOG00000045920 AllianceGenome:RGD:1589771
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ccdc109a
Summary: Enables uniporter activity. Involved in mitochondrial calcium ion transmembrane transport and positive regulation of mitochondrial calcium ion concentration. Located in mitochondrial inner membrane. Orthologous to human MCU (mitochondrial calcium uniporter). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 138.2), Brain (RPKM 97.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (27960520..28123103, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (27417529..27580110, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (29037452..29199224, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MCU overexpression evokes disparate dose-dependent effects on mito-ROS and spontaneous Ca(2+) release in hypertrophic rat cardiomyocytes.
Title: MCU overexpression evokes disparate dose-dependent effects on mito-ROS and spontaneous Ca(2+) release in hypertrophic rat cardiomyocytes.
This study, identified the role of the Pyk2/MCU pathway in the regulation of mitochondrial Ca2+ uptake and apoptotic signaling after ischemic stroke.
Title: The Pyk2/MCU pathway in the rat middle cerebral artery occlusion model of ischemic stroke.
It has been shown that the propagation of the TRPV1-induced cytosolic calcium and sodium fluxes into mitochondria is dependent on coordinated activity of NCLX and MCU.
Title: Privileged crosstalk between TRPV1 channels and mitochondrial calcium shuttling machinery controls nociception.
MCU and EMRE proteins were mainly targeting to the IMM-outer mitochondrial membrane.
Title: Strategic Positioning and Biased Activity of the Mitochondrial Calcium Uniporter in Cardiac Muscle.
Results suggest that both MCU and MICU1 are involved in mitochondrial Ca(2+) uptake in mast cells, while MCU plays a role in mast cell degranulation.
Title: Impaired expression of the mitochondrial calcium uniporter suppresses mast cell degranulation.
These findings strongly suggest that MCU could be the major route for iron uptake into cardiac mitochondria
Title: Blockade of mitochondrial calcium uniporter prevents cardiac mitochondrial dysfunction caused by iron overload.
study demonstrated that the MCU regulates the process of mitochondrial fission by controlling the Ca(2+) transport, directly upregulating mitochondrial fission proteins Drp1, Fis1 and indirectly reversing the MIEF1-induced mitochondrial fusion
Title: The effect of mitochondrial calcium uniporter on mitochondrial fission in hippocampus cells ischemia/reperfusion injury.
Cardiac responses to beta-adrenoceptor stimulation is partly dependent on mitochondrial calcium uniporter activity
Title: Cardiac responses to β-adrenoceptor stimulation is partly dependent on mitochondrial calcium uniporter activity.
Blockage of MCU could alleviate iron accumulation and the associated injury following subarachnoid hemorrhage.
Title: Blockage of mitochondrial calcium uniporter prevents iron accumulation in a model of experimental subarachnoid hemorrhage.
The results of this study indicated that MCU may be related to mitochondrial fission via modulating mitochondrial Ca2+ uptake and this relationship between MCU and mitochondrial fission may protect the brain from I/R injury.
Title: Role of mitochondrial calcium uniporter in regulating mitochondrial fission in the cerebral cortexes of living rats.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables uniporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables uniporter activity	IDA Inferred from Direct Assay more info	PubMed
enables uniporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables uniporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium import into the mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium import into the mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion starvation	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mitochondrial calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in protein complex oligomerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of calcium channel complex	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of uniplex complex	IBA Inferred from Biological aspect of Ancestor more info
part_of uniplex complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calcium uniporter protein, mitochondrial

Names: coiled-coil domain containing 109A; coiled-coil domain-containing protein 109A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106398.1 → NP_001099868.1 calcium uniporter protein, mitochondrial precursor

See identical proteins and their annotated locations for NP_001099868.1

Status: PROVISIONAL

Source sequence(s)

CH474016

UniProtKB/TrEMBL

A0A0G2K059, A6K3V1

Related

ENSRNOP00000071314.2, ENSRNOT00000090771.3

Conserved Domains (1) summary

pfam04678
Location:117 → 319

MCU; Mitochondrial calcium uniporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

27960520..28123103 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098623.2 → XP_038954551.1 calcium uniporter protein, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8I6A2V9, M0RDI5

Conserved Domains (1) summary

pfam04678
Location:77 → 279

MCU; Mitochondrial calcium uniporter
XM_039098624.2 → XP_038954552.1 calcium uniporter protein, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8I6A2V9, M0RDI5

Conserved Domains (1) summary

pfam04678
Location:77 → 279

MCU; Mitochondrial calcium uniporter