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    Tbc1d7 TBC1 domain family, member 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361227, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tbc1d7provided by RGD
    Official Full Name
    TBC1 domain family, member 7provided by RGD
    Primary source
    RGD:1307661
    See related
    EnsemblRapid:ENSRNOG00000014019 AllianceGenome:RGD:1307661
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity; TSC1-TSC2 complex binding activity; and small GTPase binding activity. Predicted to be involved in several processes, including activation of GTPase activity; negative regulation of TORC1 signaling; and negative regulation of cilium assembly. Predicted to be located in ciliary basal body; cytoplasmic vesicle; and cytosol. Predicted to be part of TSC1-TSC2 complex. Predicted to be active in lysosomal membrane. Orthologous to human TBC1D7 (TBC1 domain family member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 31.1), Brain (RPKM 29.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tbc1d7 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (21736898..21754499)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (21530709..21548556)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (23774793..23792389, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene Gfo/Idh/MocA-like oxidoreductase domain containing 1 Neighboring gene uncharacterized LOC102547830 Neighboring gene eukaryotic translation initiation factor 1-like Neighboring gene uncharacterized LOC134482703 Neighboring gene phosphatase and actin regulator 1 Neighboring gene uncharacterized LOC134482770

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of mTORC1 by PI3K signaling. Dibble CC, et al. Trends Cell Biol, 2015 Sep. PMID 26159692, Free PMC Article
    2. Identification of TBC7 having TBC domain as a novel binding protein to TSC1-TSC2 complex. Nakashima A, et al. Biochem Biophys Res Commun, 2007 Sep 14. PMID 17658474
    3. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Dibble CC, et al. Mol Cell, 2012 Aug 24. PMID 22795129, Free PMC Article
    4. Functional dissection of Rab GTPases involved in primary cilium formation. Yoshimura S, et al. J Cell Biol, 2007 Jul 30. PMID 17646400, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TSC1-TSC2 complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to growth factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TSC1-TSC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TSC1-TSC2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108411.1 → NP_001101881.1  TBC1 domain family member 7

      See identical proteins and their annotated locations for NP_001101881.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473977
      UniProtKB/TrEMBL
      A0A8I5ZX17, A6J751
      Conserved Domains (1) summary
      cl02495
      Location:147 → 247
      RabGAP-TBC; Rab-GTPase-TBC domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      21736898..21754499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276577.1 → XP_063132647.1  TBC1 domain family member 7 isoform X8

    2. XM_039095869.2 → XP_038951797.1  TBC1 domain family member 7 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZX17
      Related
      ENSRNOP00000108977.1, ENSRNOT00000143207.1
      Conserved Domains (1) summary
      cl02495
      Location:166 → 272
      RabGAP-TBC; Rab-GTPase-TBC domain

    3. XM_063276572.1 → XP_063132642.1  TBC1 domain family member 7 isoform X4

    4. XM_063276573.1 → XP_063132643.1  TBC1 domain family member 7 isoform X5

    5. XM_006253831.5 → XP_006253893.1  TBC1 domain family member 7 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZX17
      Related
      ENSRNOP00000019089.4, ENSRNOT00000019089.8
      Conserved Domains (1) summary
      cl02495
      Location:120 → 220
      RabGAP-TBC; Rab-GTPase-TBC domain

    6. XM_063276576.1 → XP_063132646.1  TBC1 domain family member 7 isoform X7

    7. XM_063276575.1 → XP_063132645.1  TBC1 domain family member 7 isoform X6

    8. XM_063276578.1 → XP_063132648.1  TBC1 domain family member 7 isoform X9

    9. XM_006253830.5 → XP_006253892.1  TBC1 domain family member 7 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZX17, D4AAY4
      Related
      ENSRNOP00000106262.1, ENSRNOT00000141058.1
      Conserved Domains (1) summary
      cl02495
      Location:147 → 247
      RabGAP-TBC; Rab-GTPase-TBC domain

    10. XM_063276570.1 → XP_063132640.1  TBC1 domain family member 7 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZX17

    11. XM_063276571.1 → XP_063132641.1  TBC1 domain family member 7 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZX17
    Nucleotide Protein Strain
    Heading Accession and Version

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