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    Cep126 centrosomal protein 126 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cep126provided by RGD
    Official Full Name
    centrosomal protein 126provided by RGD
    Primary source
    RGD:1563556
    See related
    EnsemblRapid:ENSRNOG00000021839 AllianceGenome:RGD:1563556
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563556
    Summary
    Predicted to be involved in cilium assembly; cytoplasmic microtubule organization; and mitotic spindle organization. Predicted to be active in centrosome; ciliary base; and midbody. Orthologous to human CEP126 (centrosomal protein 126). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 48.1), Brain (RPKM 29.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cep126 in Genome Data Viewer
    Location:
    8q11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (13485211..13552711, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (5200576..5267740, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (6237838..6305127, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene Yes1 associated transcriptional regulator Neighboring gene cilia and flagella associated protein 300 Neighboring gene PMS1 protein homolog 1-like Neighboring gene PMS1 protein homolog 1 pseudogene Neighboring gene 60S ribosomal protein L13-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cep126 is required for pericentriolar satellite localisation to the centrosome and for primary cilium formation. Bonavita R, et al. Biol Cell, 2014 Aug. PMID 24867236, Free PMC Article
    2. From midbody protein-protein interaction network construction to novel regulators in cytokinesis. Chen TC, et al. J Proteome Res, 2009 Nov. PMID 19799413
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in non-motile cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary base IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary base ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 126 kDa
    Names
    centrosomal protein 126kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427808.1 → NP_001414737.1  centrosomal protein of 126 kDa

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6JN52
      Related
      ENSRNOP00000111909.1, ENSRNOT00000164441.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      13485211..13552711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595957.3 → XP_017451446.1  centrosomal protein of 126 kDa isoform X3

      UniProtKB/TrEMBL
      A6JN52
      Related
      ENSRNOP00000104656.1, ENSRNOT00000129079.1

    2. XM_006242509.5 → XP_006242571.1  centrosomal protein of 126 kDa isoform X4

      See identical proteins and their annotated locations for XP_006242571.1

      UniProtKB/TrEMBL
      A6JN52
      Related
      ENSRNOP00000109418.1, ENSRNOT00000146889.1
      Conserved Domains (2) summary
      pfam13863
      Location:44 → 115
      DUF4200; Domain of unknown function (DUF4200)
      pfam15352
      Location:100 → 1050
      K1377; Susceptibility to monomelic amyotrophy

    3. XM_006242504.5 → XP_006242566.1  centrosomal protein of 126 kDa isoform X1

      See identical proteins and their annotated locations for XP_006242566.1

      UniProtKB/TrEMBL
      A0A8I6AET0, A6JN52
      Related
      ENSRNOP00000090687.1, ENSRNOT00000105514.2
      Conserved Domains (2) summary
      pfam13863
      Location:44 → 115
      DUF4200; Domain of unknown function (DUF4200)
      pfam15352
      Location:100 → 1050
      K1377; Susceptibility to monomelic amyotrophy

    4. XM_006242510.5 → XP_006242572.1  centrosomal protein of 126 kDa isoform X5

      See identical proteins and their annotated locations for XP_006242572.1

      UniProtKB/TrEMBL
      A6JN52, D3ZT87
      Related
      ENSRNOP00000030837.7, ENSRNOT00000029887.8
      Conserved Domains (2) summary
      pfam13863
      Location:44 → 115
      DUF4200; Domain of unknown function (DUF4200)
      pfam15352
      Location:100 → 1050
      K1377; Susceptibility to monomelic amyotrophy

    5. XM_006242505.5 → XP_006242567.1  centrosomal protein of 126 kDa isoform X2

      See identical proteins and their annotated locations for XP_006242567.1

      UniProtKB/TrEMBL
      A0A8I6AUH6, A6JN52
      Related
      ENSRNOP00000095996.1, ENSRNOT00000097345.2
      Conserved Domains (2) summary
      pfam13863
      Location:44 → 115
      DUF4200; Domain of unknown function (DUF4200)
      pfam15352
      Location:100 → 1050
      K1377; Susceptibility to monomelic amyotrophy

    6. XM_039082221.2 → XP_038938149.1  centrosomal protein of 126 kDa isoform X6

      UniProtKB/TrEMBL
      A6JN52
      Conserved Domains (1) summary
      pfam15352
      Location:1 → 860
      K1377; Susceptibility to monomelic amyotrophy

    7. XM_039082222.2 → XP_038938150.1  centrosomal protein of 126 kDa isoform X6

      UniProtKB/TrEMBL
      A6JN52
      Conserved Domains (1) summary
      pfam15352
      Location:1 → 860
      K1377; Susceptibility to monomelic amyotrophy

    8. XM_039082223.2 → XP_038938151.1  centrosomal protein of 126 kDa isoform X7

      UniProtKB/TrEMBL
      A6JN52
      Conserved Domains (2) summary
      pfam17380
      Location:46 → 145
      DUF5401; Family of unknown function (DUF5401)
      pfam15352
      Location:100 → 925
      K1377; Susceptibility to monomelic amyotrophy

    RNA

    1. XR_001839243.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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