Traf3ip2 Traf3 interacting protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Traf3ip2provided by RGD
Official Full Name: Traf3 interacting protein 2provided by RGD
Primary source: RGD:1593240
See related: EnsemblRapid:ENSRNOG00000000595 AllianceGenome:RGD:1593240
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1304768
Summary: Predicted to enable signaling receptor binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; hematopoietic or lymphoid organ development; and lymphocyte differentiation. Predicted to act upstream of or within B cell apoptotic process. Predicted to be active in cytoplasmic vesicle and nucleus. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis and psoriasis 13. Orthologous to human TRAF3IP2 (TRAF3 interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 67.2), Uterus (RPKM 57.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (44565992..44609240)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (43011405..43054654)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (44679861..44722874)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

BF410372 (e-PCR)
- UniSTS:246790

RH137093 (e-PCR)
- UniSTS:219181

RH131445 (e-PCR)
- UniSTS:214728

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell affinity maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within B cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in B cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in B cell mediated immunity	ISO Inferred from Sequence Orthology more info
involved_in CD40 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in T-helper 17 type immune response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-17	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in eosinophil homeostasis	ISO Inferred from Sequence Orthology more info
involved_in eosinophil mediated immunity	ISO Inferred from Sequence Orthology more info
involved_in establishment of T cell polarity	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in humoral immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within humoral immune response	ISO Inferred from Sequence Orthology more info
involved_in immune response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in interleukin-17-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-17A-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in kidney development	ISO Inferred from Sequence Orthology more info
involved_in leukocyte activation involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in lymph node development	ISO Inferred from Sequence Orthology more info
involved_in mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in mucus secretion	ISO Inferred from Sequence Orthology more info
involved_in neutrophil activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to P-body	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in signal transduction involved in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in skin development	ISO Inferred from Sequence Orthology more info
involved_in spleen development	ISO Inferred from Sequence Orthology more info
involved_in transitional two stage B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in type 2 immune response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin ligase TRAF3IP2

Names: adapter protein CIKS

NP_001037713.1

EC 2.3.2.27

XP_006256594.1

EC 2.3.2.27

XP_038954814.1

EC 2.3.2.27

XP_038954815.1

EC 2.3.2.27

XP_063135386.1

EC 2.3.2.27

XP_063135387.1

EC 2.3.2.27

XP_063135388.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.