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    Arpp21 cAMP regulated phosphoprotein 21 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363153, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arpp21provided by RGD
    Official Full Name
    cAMP regulated phosphoprotein 21provided by RGD
    Primary source
    RGD:1593239
    See related
    EnsemblRapid:ENSRNOG00000008919 AllianceGenome:RGD:1593239
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Arpp-21; Ppp1r1c; Ppp1r1cl; RGD1307208; RGD1307215
    Summary
    Predicted to enable nucleic acid binding activity. Predicted to act upstream of or within cellular response to heat. Predicted to be active in cytoplasm. Orthologous to human ARPP21 (cAMP regulated phosphoprotein 21). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 215.3), Brain (RPKM 172.2) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arpp21 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (120912964..121077586, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (112034636..112199273, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (120323895..120492790, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480100 Neighboring gene SH3 and cysteine rich domain Neighboring gene transfer RNA proline (anticodon AGG) 10 Neighboring gene uncharacterized LOC120094270 Neighboring gene uncharacterized LOC120094269 Neighboring gene microRNA 128-2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ARPP-21, a cyclic AMP-regulated phosphoprotein (Mr = 21,000) enriched in dopamine-innervated brain regions. Amino acid sequence of the site phosphorylated by cyclic AMP in intact cells and kinetic studies of its phosphorylation in vitro. Hemmings HC Jr, et al. J Biol Chem, 1989 May 5. PMID 2540203
    2. Characterization of rat ARPP-21 mRNA: sequence analysis, tissue distribution, and regulation. Ehrlich ME, et al. J Neurochem, 1991 Dec. PMID 1940913
    3. Activation of sodium transport in rat erythrocytes by inhibition of protein phosphatases 1 and 2A. Ivanova TI, et al. Comp Biochem Physiol B Biochem Mol Biol, 2006 Sep. PMID 16875859
    4. The RNA-binding protein ARPP21 controls dendritic branching by functionally opposing the miRNA it hosts. Rehfeld F, et al. Nat Commun, 2018 Mar 26. PMID 29581509, Free PMC Article
    5. Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling. Bailey MJ, et al. J Biol Chem, 2009 Mar 20. PMID 19103603, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of ARPP21 in the pineal gland increases at night more than 1000%. This probably reflects circadian neural stimulation by the suprachiasmatic nucleus.
      Title: Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.
    2. Inhibition of protein phosphatase 1 by protein phosphatase inhibitors activates sodiun transport in rat erytrocytes
      Title: Activation of sodium transport in rat erythrocytes by inhibition of protein phosphatases 1 and 2A.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109368

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cAMP-regulated phosphoprotein 21
    Names
    cAMP-regulated phosphoprotein (21 kDa)
    cyclic AMP-regulated phosphoprotein, 21
    protein phosphatase 1, regulatory (inhibitory subunit 1C)
    protein phosphatase 1, regulatory subunit 1C

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135045.1 → NP_001128517.1  cAMP-regulated phosphoprotein 21 isoform 2

      See identical proteins and their annotated locations for NP_001128517.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      D3ZQR3
      Related
      ENSRNOP00000039268.2, ENSRNOT00000042854.6
      Conserved Domains (3) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam11235
      Location:597 → 769
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam12752
      Location:244 → 298
      SUZ; SUZ domain

    2. NM_001135046.1 → NP_001128518.1  cAMP-regulated phosphoprotein 21 isoform 1

      See identical proteins and their annotated locations for NP_001128518.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I3K4, A6I3K8, Q5FVI0
      Related
      ENSRNOP00000033306.3, ENSRNOT00000037199.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      120912964..121077586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243975.5 → XP_006244037.1  cAMP-regulated phosphoprotein 21 isoform X1

      See identical proteins and their annotated locations for XP_006244037.1

      Conserved Domains (3) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:553 → 790
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:244 → 299
      SUZ; SUZ domain

    2. XM_039081801.2 → XP_038937729.1  cAMP-regulated phosphoprotein 21 isoform X1

      Conserved Domains (3) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:553 → 790
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:244 → 299
      SUZ; SUZ domain

    3. XM_006243974.5 → XP_006244036.1  cAMP-regulated phosphoprotein 21 isoform X1

      See identical proteins and their annotated locations for XP_006244036.1

      Conserved Domains (3) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:553 → 790
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:244 → 299
      SUZ; SUZ domain

    4. XM_063265840.1 → XP_063121910.1  cAMP-regulated phosphoprotein 21 isoform X8

    5. XM_017595751.3 → XP_017451240.1  cAMP-regulated phosphoprotein 21 isoform X1

      Conserved Domains (3) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:553 → 790
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:244 → 299
      SUZ; SUZ domain

    6. XM_006243980.5 → XP_006244042.1  cAMP-regulated phosphoprotein 21 isoform X1

      See identical proteins and their annotated locations for XP_006244042.1

      Conserved Domains (3) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:553 → 790
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:244 → 299
      SUZ; SUZ domain

    7. XM_063265841.1 → XP_063121911.1  cAMP-regulated phosphoprotein 21 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZX87

    8. XM_017595750.3 → XP_017451239.1  cAMP-regulated phosphoprotein 21 isoform X1

      Conserved Domains (3) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:553 → 790
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:244 → 299
      SUZ; SUZ domain

    9. XM_039081802.2 → XP_038937730.1  cAMP-regulated phosphoprotein 21 isoform X1

      Conserved Domains (3) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:553 → 790
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:244 → 299
      SUZ; SUZ domain

    10. XM_063265839.1 → XP_063121909.1  cAMP-regulated phosphoprotein 21 isoform X1

    11. XM_006243977.5 → XP_006244039.1  cAMP-regulated phosphoprotein 21 isoform X1

      See identical proteins and their annotated locations for XP_006244039.1

      Conserved Domains (3) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:553 → 790
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:244 → 299
      SUZ; SUZ domain

    12. XM_039081805.1 → XP_038937733.1  cAMP-regulated phosphoprotein 21 isoform X12

      Conserved Domains (2) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      PRK10263
      Location:492 → 714
      PRK10263; DNA translocase FtsK; Provisional

    13. XM_017595760.2 → XP_017451249.1  cAMP-regulated phosphoprotein 21 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZX87

    14. XM_017595758.2 → XP_017451247.1  cAMP-regulated phosphoprotein 21 isoform X8

    15. XM_039081804.1 → XP_038937732.1  cAMP-regulated phosphoprotein 21 isoform X11

      Conserved Domains (2) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      PRK10263
      Location:512 → 734
      PRK10263; DNA translocase FtsK; Provisional

    16. XM_017595756.2 → XP_017451245.1  cAMP-regulated phosphoprotein 21 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A885
      Related
      ENSRNOP00000087306.1, ENSRNOT00000100209.2
      Conserved Domains (1) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...

    17. XM_039081803.1 → XP_038937731.1  cAMP-regulated phosphoprotein 21 isoform X6

      Conserved Domains (3) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:532 → 769
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:244 → 298
      SUZ; SUZ domain

    18. XM_017595754.2 → XP_017451243.1  cAMP-regulated phosphoprotein 21 isoform X4

    19. XM_017595752.2 → XP_017451241.1  cAMP-regulated phosphoprotein 21 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JVX9
      Conserved Domains (2) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam12752
      Location:244 → 298
      SUZ; SUZ domain

    20. XM_017595755.2 → XP_017451244.1  cAMP-regulated phosphoprotein 21 isoform X5

      Related
      ENSRNOP00000083589.2, ENSRNOT00000100319.2
      Conserved Domains (2) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam12752
      Location:244 → 299
      SUZ; SUZ domain

    21. XM_017595753.2 → XP_017451242.1  cAMP-regulated phosphoprotein 21 isoform X3

      Conserved Domains (2) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam12752
      Location:244 → 299
      SUZ; SUZ domain

    22. XM_017595757.2 → XP_017451246.1  cAMP-regulated phosphoprotein 21 isoform X9

      Conserved Domains (3) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam11235
      Location:598 → 770
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam12752
      Location:244 → 299
      SUZ; SUZ domain

    23. XM_006243972.4 → XP_006244034.1  cAMP-regulated phosphoprotein 21 isoform X1

      See identical proteins and their annotated locations for XP_006244034.1

      Conserved Domains (3) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:553 → 790
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:244 → 299
      SUZ; SUZ domain

    24. XM_006243976.5 → XP_006244038.1  cAMP-regulated phosphoprotein 21 isoform X1

      See identical proteins and their annotated locations for XP_006244038.1

      Related
      ENSRNOP00000069661.2, ENSRNOT00000085161.3
      Conserved Domains (3) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:553 → 790
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:244 → 299
      SUZ; SUZ domain

    25. XM_006243973.5 → XP_006244035.1  cAMP-regulated phosphoprotein 21 isoform X1

      See identical proteins and their annotated locations for XP_006244035.1

      Conserved Domains (3) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:553 → 790
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:244 → 299
      SUZ; SUZ domain

    26. XM_006243982.5 → XP_006244044.1  cAMP-regulated phosphoprotein 21 isoform X1

      See identical proteins and their annotated locations for XP_006244044.1

      Conserved Domains (3) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
      pfam09606
      Location:553 → 790
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam12752
      Location:244 → 299
      SUZ; SUZ domain

    27. XM_039081806.1 → XP_038937734.1  cAMP-regulated phosphoprotein 21 isoform X13

      UniProtKB/TrEMBL
      A6I3J9
      Conserved Domains (2) summary
      PRK14971
      Location:334 → 457
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam12752
      Location:5 → 35
      SUZ; SUZ domain

    28. XM_017595766.3 → XP_017451255.1  cAMP-regulated phosphoprotein 21 isoform X14

      UniProtKB/TrEMBL
      A0A8I5ZKF3
      Conserved Domains (1) summary
      cd02642
      Location:162 → 223
      R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...

    29. XM_063265843.1 → XP_063121913.1  cAMP-regulated phosphoprotein 21 isoform X15

      UniProtKB/TrEMBL
      A6I3K4, A6I3K8, Q5FVI0

    30. XM_063265844.1 → XP_063121914.1  cAMP-regulated phosphoprotein 21 isoform X15

      UniProtKB/TrEMBL
      A6I3K4, A6I3K8, Q5FVI0

    31. XM_017595769.3 → XP_017451258.1  cAMP-regulated phosphoprotein 21 isoform X15

      UniProtKB/TrEMBL
      A6I3K4, A6I3K8, Q5FVI0

    32. XM_039081807.2 → XP_038937735.1  cAMP-regulated phosphoprotein 21 isoform X15

      UniProtKB/TrEMBL
      A6I3K4, A6I3K8, Q5FVI0

    33. XM_063265842.1 → XP_063121912.1  cAMP-regulated phosphoprotein 21 isoform X15

      UniProtKB/TrEMBL
      A6I3K4, A6I3K8, Q5FVI0
    Nucleotide Protein Strain
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