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    Nubp2 NUBP iron-sulfur cluster assembly factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287125, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nubp2provided by RGD
    Official Full Name
    NUBP iron-sulfur cluster assembly factor 2provided by RGD
    Primary source
    RGD:1305113
    See related
    EnsemblRapid:ENSRNOG00000015090 AllianceGenome:RGD:1305113
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable iron-sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly. Predicted to be located in nucleus and spindle pole centrosome. Predicted to be active in cytosol. Orthologous to human NUBP2 (NUBP iron-sulfur cluster assembly factor 2, cytosolic). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 236.4), Thymus (RPKM 208.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nubp2 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14407743..14411428, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13903224..13906928, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14244201..14247930, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene transfer RNA proline (anticodon AGG) 67 Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene insulin-like growth factor binding protein, acid labile subunit Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3 Neighboring gene essential meiotic structure-specific endonuclease subunit 2 Neighboring gene mitochondrial ribosomal protein S34

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is implicated in the regulation of centrosome duplication. Christodoulou A, et al. J Cell Sci, 2006 May 15. PMID 16638812
    2. Biogenesis of cytosolic and nuclear iron-sulfur proteins and their role in genome stability. Paul VD, et al. Biochim Biophys Acta, 2015 Jun. PMID 25583461
    3. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N, et al. Biochim Biophys Acta, 2015 Jun. PMID 25245479, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent FeS chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic Fe-S cluster assembly factor NUBP2
    Names
    NBP 2
    nucleotide binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011891.1 → NP_001011891.1  cytosolic Fe-S cluster assembly factor NUBP2

      See identical proteins and their annotated locations for NP_001011891.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079386
      UniProtKB/Swiss-Prot
      Q68FS1
      UniProtKB/TrEMBL
      A0A8I5ZU76, A6HCY0
      Related
      ENSRNOP00000083949.2, ENSRNOT00000120075.2
      Conserved Domains (2) summary
      COG0455
      Location:15 → 263
      FlhG; MinD-like ATPase involved in chromosome partitioning or flagellar assembly [Cell cycle control, cell division, chromosome partitioning, Cell motility]
      pfam10609
      Location:12 → 263
      ParA; NUBPL iron-transfer P-loop NTPase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      14407743..14411428 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767558.4 → XP_008765780.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform X1

      Conserved Domains (2) summary
      COG0489
      Location:13 → 172
      Mrp; Chromosome partitioning ATPase, Mrp family, contains Fe-S cluster [Cell cycle control, cell division, chromosome partitioning]
      cl21455
      Location:1 → 203
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FS1.1 GenPept UniProtKB/Swiss-Prot:Q68FS1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools