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    Mapre2 microtubule-associated protein, RP/EB family, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 679221, updated on 9-Dec-2024

    Summary

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    Symbol
    Mapre2provided by RGD
    Full Name
    microtubule-associated protein, RP/EB family, member 2provided by RGD
    Primary source
    RGD:1590736
    See related
    EnsemblRapid:ENSRNOG00000049681 AllianceGenome:RGD:1590736
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity; microtubule plus-end binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including positive regulation of ARF protein signal transduction; positive regulation of focal adhesion disassembly; and positive regulation of keratinocyte migration. Predicted to be located in focal adhesion and microtubule cytoskeleton. Predicted to be active in microtubule cytoskeleton. Human ortholog(s) of this gene implicated in congenital symmetric circumferential skin creases 2. Orthologous to human MAPRE2 (microtubule associated protein RP/EB family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 447.8), Heart (RPKM 340.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mapre2 in Genome Data Viewer
    Location:
    18p12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (15303502..15444306)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (15028675..15169553)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (14814149..15780290)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098122 Neighboring gene ribosomal protein L10, pseudogene 14 Neighboring gene uncharacterized LOC120098207 Neighboring gene uncharacterized LOC134482919 Neighboring gene uncharacterized LOC134482918 Neighboring gene uncharacterized LOC134482917 Neighboring gene uncharacterized LOC134482920 Neighboring gene zinc finger protein 397

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. EB1 and EB3 control CLIP dissociation from the ends of growing microtubules. Komarova Y, et al. Mol Biol Cell, 2005 Nov. PMID 16148041, Free PMC Article
    2. Microtubules regulate focal adhesion dynamics through MAP4K4. Yue J, et al. Dev Cell, 2014 Dec 8. PMID 25490267, Free PMC Article
    3. Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Sigal A, et al. Nat Methods, 2006 Jul. PMID 16791210
    4. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. Popiolek M, et al. J Biol Chem, 2011 Aug 19. PMID 21700703, Free PMC Article
    5. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ARF protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of focal adhesion disassembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of focal adhesion disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of keratinocyte migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of keratinocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated protein RP/EB family member 2
    Names
    microtubule-associated protein RP/EB family member 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101000.1 → NP_001094470.1  microtubule-associated protein RP/EB family member 2

      See identical proteins and their annotated locations for NP_001094470.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105879
      UniProtKB/Swiss-Prot
      Q3B8Q0
      UniProtKB/TrEMBL
      A6J2I9, M0R8A4
      Related
      ENSRNOP00000065698.4, ENSRNOT00000075444.4
      Conserved Domains (1) summary
      COG5217
      Location:58 → 315
      BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      15303502..15444306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097097.2 → XP_038953025.1  microtubule-associated protein RP/EB family member 2 isoform X2

      UniProtKB/TrEMBL
      M0R8A4
      Related
      ENSRNOP00000111294.1, ENSRNOT00000139457.1
      Conserved Domains (1) summary
      COG5217
      Location:16 → 273
      BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

    2. XM_039097095.2 → XP_038953023.1  microtubule-associated protein RP/EB family member 2 isoform X1

      UniProtKB/TrEMBL
      A6J2I8, M0R7M8, M0R8A4
      Related
      ENSRNOP00000065460.3, ENSRNOT00000071364.4
      Conserved Domains (1) summary
      COG5217
      Location:51 → 308
      BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3B8Q0.1 GenPept UniProtKB/Swiss-Prot:Q3B8Q0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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