Blmh bleomycin hydrolase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Blmhprovided by RGD
Official Full Name: bleomycin hydrolaseprovided by RGD
Primary source: RGD:1304668
See related: EnsemblRapid:ENSRNOG00000003563 AllianceGenome:RGD:1304668
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable aminopeptidase activity; cysteine-type peptidase activity; and identical protein binding activity. Predicted to be involved in homocysteine catabolic process and response to toxic substance. Predicted to act upstream of or within response to xenobiotic stimulus. Predicted to be active in cytoplasm. Orthologous to human BLMH (bleomycin hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 250.0), Lung (RPKM 213.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (62270170..62313349)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (61772112..61815212)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (63197367..63240447, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Blmh was localized as granular staining in the distal and proximal tubular cells of the kidney, and it was also detected in hepatocytes of the liver, in the red pulpy region of the spleen and in neurons of the brain.
Title: Quantification of neutral cysteine protease bleomycin hydrolase and its localization in rat tissues.
processing specificity of bleomycin hydrolase depends upon the structure and sequence of amyloid beta-peptides
Title: Processing of amyloid beta-peptides by neutral cysteine protease bleomycin hydrolase.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:236646 (e-PCR)
- UniSTS:236646

RH138491 (e-PCR)
- UniSTS:220578

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aminopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in homocysteine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: bleomycin hydrolase

Names: BH; BLM hydrolase; BMH

NP_001029335.1

EC 3.4.22.40

XP_038941468.1

EC 3.4.22.40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034163.1 → NP_001029335.1 bleomycin hydrolase

See identical proteins and their annotated locations for NP_001029335.1

Status: VALIDATED

Source sequence(s)

CB583895, CB768995, CB772927, CB774190, CK363809, JAXUCZ010000010

UniProtKB/Swiss-Prot

P70645

UniProtKB/TrEMBL

A1A5L1

Related

ENSRNOP00000088070.1, ENSRNOT00000119015.2

Conserved Domains (1) summary

pfam03051
Location:5 → 451

Peptidase_C1_2; Peptidase C1-like family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

62270170..62313349

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085540.2 → XP_038941468.1 bleomycin hydrolase isoform X1

UniProtKB/TrEMBL

A6HGW8

Conserved Domains (1) summary

cl23744
Location:5 → 267

Peptidase_C1; C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some ...