Cmklr2 chemerin chemokine-like receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cmklr2provided by RGD
Official Full Name: chemerin chemokine-like receptor 2provided by RGD
Primary source: RGD:2728
See related: EnsemblRapid:ENSRNOG00000045532 AllianceGenome:RGD:2728
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr1
Summary: Predicted to enable several functions, including adipokinetic hormone binding activity; adipokinetic hormone receptor activity; and neuropeptide binding activity. Predicted to be involved in glucose homeostasis and neuropeptide signaling pathway. Predicted to be located in nucleoplasm. Predicted to be active in neuron projection and plasma membrane. Orthologous to human CMKLR2 (chemerin chemokine-like receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 5.5), Heart (RPKM 1.5) and 5 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 9q32

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (72077164..72111979, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (64583310..64617883, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (69958607..69991410, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CMKLR1 and GPR1 were widely expressed in vascular smooth muscle.
Title: Chemerin Elicits Potent Constrictor Actions via Chemokine-Like Receptor 1 (CMKLR1), not G-Protein-Coupled Receptor 1 (GPR1), in Human and Rat Vasculature.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:546800

Gpr1 (e-PCR), detects polymorphism
- UniSTS:546800

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables adipokinetic hormone binding	ISO Inferred from Sequence Orthology more info
enables adipokinetic hormone binding	ISS Inferred from Sequence or Structural Similarity more info
enables adipokinetic hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables adipokinetic hormone receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: chemerin-like receptor 2

Names: G protein-coupled receptor 1; G-protein copled receptor 1; chemokine-like receptor 2; probable G-protein coupled receptor 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012961.2 → NP_037093.2 chemerin-like receptor 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

M0RCK7, P46090

Related

ENSRNOP00000102895.1, ENSRNOT00000174111.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

72077164..72111979 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063266682.1 → XP_063122752.1 chemerin-like receptor 2 isoform X1

UniProtKB/Swiss-Prot

M0RCK7, P46090

Related

ENSRNOP00000104826.1, ENSRNOT00000123700.1
XM_039083036.1 → XP_038938964.1 chemerin-like receptor 2 isoform X1

UniProtKB/Swiss-Prot

M0RCK7, P46090

Conserved Domains (1) summary

cd15119
Location:39 → 313

7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors