Cap1 cyclase associated actin cytoskeleton regulatory protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cap1provided by RGD
Official Full Name: cyclase associated actin cytoskeleton regulatory protein 1provided by RGD
Primary source: RGD:620309
See related: EnsemblRapid:ENSRNOG00000013492 AllianceGenome:RGD:620309
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mch1
Summary: Predicted to enable actin binding activity and adenylate cyclase binding activity. Predicted to be involved in several processes, including actin filament organization; cAMP-mediated signaling; and modification of postsynaptic actin cytoskeleton. Predicted to act upstream of or within actin cytoskeleton organization; ameboidal-type cell migration; and receptor-mediated endocytosis. Predicted to be located in cortical actin cytoskeleton. Predicted to be active in several cellular components, including glutamatergic synapse; postsynapse; and presynapse. Orthologous to human CAP1 (cyclase associated actin cytoskeleton regulatory protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 734.1), Thymus (RPKM 537.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (140427265..140507678, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (135142108..135168885, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (140559195..140585494, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CAP1 binds and activates adenylyl cyclase in mammalian cells.
Title: CAP1 binds and activates adenylyl cyclase in mammalian cells.
Hippocampal Cap1 levels is sensitive to different exercise intensities.Highest corticosterone level and lactate production leads to reduction and induction of hippocampal Cap1.
Title: Various exercise intensities differentially regulate GAP-43 and CAP-1 expression in the rat hippocampus.
Upregulation of CAP1 protein expression was associated with astrocyte proliferation after the trauma of the central nervous system.
Title: The expression of CAP1 after traumatic brain injury and its role in astrocyte proliferation.
CAP1 was associated with actin and involved in Schwann cell differentiation and motility after sciatic nerve injury.
Title: CAP1 was associated with actin and involved in Schwann cell differentiation and motility after sciatic nerve injury.
Cap1 regulates growth cone morphology through rearrangement of F-actin and thereby controls neurite outgrowth.
Title: Expression and function of neuronal growth-associated proteins (nGAPs) in PC12 cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:237169 (e-PCR)
- UniSTS:237169

RH127550 (e-PCR)
- UniSTS:210860

AA851880 (e-PCR)
- UniSTS:261824

RH142418 (e-PCR)
- UniSTS:231665

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in ameboidal-type cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ameboidal-type cell migration	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in modification of postsynaptic actin cytoskeleton	IEA Inferred from Electronic Annotation more info
involved_in modification of postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cortical actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenylyl cyclase-associated protein 1

Names: CAP 1; CAP, adenylate cyclase-associated protein 1; adenylate cyclase associated protein 1; cyclase-associated protein homologue

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001430080.1 → NP_001417009.1 adenylyl cyclase-associated protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q08163, Q5FVS8

UniProtKB/TrEMBL

A0A8L2QAE6, A6IS11
NM_001430081.1 → NP_001417010.1 adenylyl cyclase-associated protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q08163, Q5FVS8

UniProtKB/TrEMBL

A0A8L2QAE6, A6IS11
NM_001430082.1 → NP_001417011.1 adenylyl cyclase-associated protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q08163, Q5FVS8

UniProtKB/TrEMBL

A0A8L2QAE6, A6IS11
NM_001430083.1 → NP_001417012.1 adenylyl cyclase-associated protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q08163, Q5FVS8

UniProtKB/TrEMBL

A0A8L2QAE6, A6IS11
NM_001430084.1 → NP_001417013.1 adenylyl cyclase-associated protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q08163, Q5FVS8

UniProtKB/TrEMBL

A0A8L2QAE6, A6IS11
NM_001430085.1 → NP_001417014.1 adenylyl cyclase-associated protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q08163, Q5FVS8

UniProtKB/TrEMBL

A0A8L2QAE6, A6IS11
NM_001430086.1 → NP_001417015.1 adenylyl cyclase-associated protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q08163, Q5FVS8

UniProtKB/TrEMBL

A0A8L2QAE6, A6IS11
NM_001430087.1 → NP_001417016.1 adenylyl cyclase-associated protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q08163, Q5FVS8

UniProtKB/TrEMBL

A0A8L2QAE6, A6IS11
NM_022383.5 → NP_071778.2 adenylyl cyclase-associated protein 1

See identical proteins and their annotated locations for NP_071778.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q08163, Q5FVS8

UniProtKB/TrEMBL

A0A8L2QAE6, A6IS11

Related

ENSRNOP00000018711.5, ENSRNOT00000018711.6

Conserved Domains (2) summary

pfam01213
Location:5 → 61

CAP_N; Adenylate cyclase associated (CAP) N terminal

pfam08603
Location:318 → 472

CAP_C; Adenylate cyclase associated (CAP) C terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

140427265..140507678 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063288342.1 → XP_063144412.1 adenylyl cyclase-associated protein 1 isoform X1

UniProtKB/Swiss-Prot

Q08163, Q5FVS8

UniProtKB/TrEMBL

A0A8L2QAE6, A6IS11
XM_063288341.1 → XP_063144411.1 adenylyl cyclase-associated protein 1 isoform X1

UniProtKB/Swiss-Prot

Q08163, Q5FVS8

UniProtKB/TrEMBL

A0A8L2QAE6, A6IS11
XM_039110702.2 → XP_038966630.1 adenylyl cyclase-associated protein 1 isoform X1

UniProtKB/Swiss-Prot

Q08163, Q5FVS8

UniProtKB/TrEMBL

A0A8L2QAE6, A6IS11

Conserved Domains (2) summary

pfam01213
Location:5 → 61

CAP_N; Adenylate cyclase associated (CAP) N terminal

pfam08603
Location:318 → 472

CAP_C; Adenylate cyclase associated (CAP) C terminal
XM_063288346.1 → XP_063144416.1 adenylyl cyclase-associated protein 1 isoform X1

UniProtKB/Swiss-Prot

Q08163, Q5FVS8

UniProtKB/TrEMBL

A0A8L2QAE6, A6IS11
XM_006238830.5 → XP_006238892.1 adenylyl cyclase-associated protein 1 isoform X1

Conserved Domains (2) summary

pfam01213
Location:5 → 61

CAP_N; Adenylate cyclase associated (CAP) N terminal

pfam08603
Location:318 → 472

CAP_C; Adenylate cyclase associated (CAP) C terminal
XM_006238832.5 → XP_006238894.1 adenylyl cyclase-associated protein 1 isoform X1

Conserved Domains (2) summary

pfam01213
Location:5 → 61

CAP_N; Adenylate cyclase associated (CAP) N terminal

pfam08603
Location:318 → 472

CAP_C; Adenylate cyclase associated (CAP) C terminal
XM_006238831.5 → XP_006238893.1 adenylyl cyclase-associated protein 1 isoform X1

Conserved Domains (2) summary

pfam01213
Location:5 → 61

CAP_N; Adenylate cyclase associated (CAP) N terminal

pfam08603
Location:318 → 472

CAP_C; Adenylate cyclase associated (CAP) C terminal
XM_063288340.1 → XP_063144410.1 adenylyl cyclase-associated protein 1 isoform X1

UniProtKB/Swiss-Prot

Q08163, Q5FVS8

UniProtKB/TrEMBL

A0A8L2QAE6, A6IS11
XM_063288344.1 → XP_063144414.1 adenylyl cyclase-associated protein 1 isoform X1
XM_063288345.1 → XP_063144415.1 adenylyl cyclase-associated protein 1 isoform X1
XM_063288343.1 → XP_063144413.1 adenylyl cyclase-associated protein 1 isoform X1

UniProtKB/Swiss-Prot

Q08163, Q5FVS8

UniProtKB/TrEMBL

A0A8L2QAE6, A6IS11
XM_039110703.2 → XP_038966631.1 adenylyl cyclase-associated protein 1 isoform X1

Conserved Domains (2) summary

pfam01213
Location:5 → 61

CAP_N; Adenylate cyclase associated (CAP) N terminal

pfam08603
Location:318 → 472

CAP_C; Adenylate cyclase associated (CAP) C terminal