Cfi complement factor I [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cfiprovided by RGD
Official Full Name: complement factor Iprovided by RGD
Primary source: RGD:620429
See related: EnsemblRapid:ENSRNOG00000053400 AllianceGenome:RGD:620429
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: FI
Summary: Predicted to enable metal ion binding activity and serine-type endopeptidase activity. Involved in cellular response to interleukin-6. Located in extracellular space. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; age related macular degeneration 13; atypical hemolytic-uremic syndrome; complement factor I deficiency; and macular degeneration. Orthologous to human CFI (complement factor I). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 2970.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q43

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (221062206..221104790)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (218389079..218430565)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (235264149..235305779)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

d2mgh29 (e-PCR)
- UniSTS:121600

RH128544 (e-PCR)
- UniSTS:211852

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to interleukin-6	IEP Inferred from Expression Pattern more info	PubMed
involved_in complement activation	IEA Inferred from Electronic Annotation more info
involved_in complement activation	ISO Inferred from Sequence Orthology more info
involved_in complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: complement factor I

Names: C3B/C4B inactivator

NP_077071.1

EC 3.4.21.45

XP_063138678.1

EC 3.4.21.45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024157.1 → NP_077071.1 complement factor I precursor

See identical proteins and their annotated locations for NP_077071.1

Status: PROVISIONAL

Source sequence(s)

Y18965

UniProtKB/Swiss-Prot

Q5EBC4, Q9WUW3

UniProtKB/TrEMBL

A0A8I6AC86

Related

ENSRNOP00000071685.2, ENSRNOT00000086245.3

Conserved Domains (7) summary

smart00192
Location:228 → 258

LDLa; Low-density lipoprotein receptor domain class A

smart00020
Location:361 → 590

Tryp_SPc; Trypsin-like serine protease

smart00057
Location:46 → 111

FIMAC; factor I membrane attack complex

smart00202
Location:117 → 220

SR; Scavenger receptor Cys-rich

cd00190
Location:362 → 591

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00530
Location:122 → 219

SRCR; Scavenger receptor cysteine-rich domain

cl00104
Location:264 → 298

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...