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    Pax8 paired box 8 [ Mus musculus (house mouse) ]

    Gene ID: 18510, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pax8provided by MGI
    Official Full Name
    paired box 8provided by MGI
    Primary source
    MGI:MGI:97492
    See related
    Ensembl:ENSMUSG00000026976 AllianceGenome:MGI:97492
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pax-8
    Summary
    This gene encodes a member of a family of transcription factors that contain a characteristic N-terminal paired DNA-binding domain. The encoded protein is important for proper differentiation of the thyroid and the kidney. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Mar 2013]
    Expression
    Biased expression in genital fat pad adult (RPKM 36.6), kidney adult (RPKM 27.4) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pax8 in Genome Data Viewer
    Location:
    2 A3; 2 16.43 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24310563..24365611, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24420551..24475599, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor antagonist Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:24238515-24238668 Neighboring gene STARR-positive B cell enhancer ABC_E11125 Neighboring gene pleckstrin and Sec7 domain containing 4 Neighboring gene predicted gene 13415 Neighboring gene Pax8 promoter region Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene Pax8 CNS1 enhancer Neighboring gene predicted gene, 39769 Neighboring gene Pax8 CNS87 enhancer

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in S-shaped body morphogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in branching involved in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to gonadotropin stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to gonadotropin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in central nervous system development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inner ear morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in kidney epithelium development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in mesenchymal to epithelial transition involved in metanephros morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesonephric tubule development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in mesonephros development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in mesonephros development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in metanephric S-shaped body morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metanephric comma-shaped body morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metanephric distal convoluted tubule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in metanephric nephron tubule formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in metanephros development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within metanephros development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of apoptotic process involved in metanephric collecting duct development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process involved in metanephric nephron tubule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cardiac muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of mesenchymal cell apoptotic process involved in metanephros development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in otic vesicle development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of branching involved in ureteric bud morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of metanephric DCT cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of thyroid hormone generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of thyroid hormone generation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pronephric field specification IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in pronephros development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of metanephric nephron tubule epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of thyroid-stimulating hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of thyroid-stimulating hormone secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sulfur compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thyroid gland development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within thyroid gland development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within thyroid gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in thyroid gland development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in urogenital system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in ventricular septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    paired box protein Pax-8
    Names
    paired box gene 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011040.4NP_035170.1  paired box protein Pax-8

      See identical proteins and their annotated locations for NP_035170.1

      Status: REVIEWED

      Source sequence(s)
      AK050717, AL732528, BY442465
      Consensus CDS
      CCDS15738.1
      UniProtKB/Swiss-Prot
      P97342, Q00288, Q6GU20
      UniProtKB/TrEMBL
      A2AIU7
      Related
      ENSMUSP00000028355.5, ENSMUST00000028355.11
      Conserved Domains (2) summary
      smart00351
      Location:9133
      PAX; Paired Box domain
      pfam12403
      Location:344455
      Pax2_C; Paired-box protein 2 C terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      24310563..24365611 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)