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    Ddit3 DNA-damage inducible transcript 3 [ Mus musculus (house mouse) ]

    Gene ID: 13198, updated on 3-Dec-2024

    Summary

    Official Symbol
    Ddit3provided by MGI
    Official Full Name
    DNA-damage inducible transcript 3provided by MGI
    Primary source
    MGI:MGI:109247
    See related
    Ensembl:ENSMUSG00000025408 AllianceGenome:MGI:109247
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    chop; CHOP10; CHOP-10; gadd153; AltDDIT3
    Summary
    Enables several functions, including DNA-binding transcription factor binding activity; protein heterodimerization activity; and transcription regulator activator activity. Involved in several processes, including blood vessel development; intracellular signal transduction; and regulation of transcription by RNA polymerase II. Acts upstream of or within ER overload response; negative regulation of fat cell differentiation; and sensory perception of sound. Located in late endosome and nucleus. Part of CHOP-C/EBP complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Orthologous to human DDIT3 (DNA damage inducible transcript 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 13.2), ovary adult (RPKM 9.0) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ddit3 in Genome Data Viewer
    Location:
    10 D3; 10 74.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127126662..127132160)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127290793..127296291)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 5A Neighboring gene STARR-positive B cell enhancer ABC_E9810 Neighboring gene predicted gene, 40800 Neighboring gene dynactin 2 Neighboring gene STARR-positive B cell enhancer ABC_E10652 Neighboring gene STARR-positive B cell enhancer ABC_E1410 Neighboring gene STARR-positive B cell enhancer ABC_E6939 Neighboring gene methyl-CpG binding domain protein 6 Neighboring gene methionine-tRNA synthetase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:126748829-126749012 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10653 Neighboring gene Rho GTPase activating protein 9 Neighboring gene GLI-Kruppel family member GLI1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cAMP response element binding protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cAMP response element binding protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables leucine zipper domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables leucine zipper domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription regulator activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription regulator inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription regulator inhibitor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ER overload response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within ER overload response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ER overload response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in HRI-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anterior/posterior axis specification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in artery development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in blood vessel maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell redox homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum unfolded protein response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within endoplasmic reticulum unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of protein localization to mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in integrated stress response signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to nitrosative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of determination of dorsal identity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of determination of dorsal identity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of fat cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of interleukin-17 production IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of negative regulation of interleukin-17 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-4 production IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of negative regulation of interleukin-4 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of type II interferon production IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of negative regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagy in response to ER overload ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-8 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intrinsic apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in release of sequestered calcium ion into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to platelet-derived growth factor IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to unfolded protein ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sensory perception of sound IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in vascular associated smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vascular associated smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CHOP-ATF3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of CHOP-ATF3 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of CHOP-ATF3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of CHOP-ATF4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of CHOP-ATF4 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of CHOP-ATF4 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of CHOP-C/EBP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of CHOP-C/EBP complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of CHOP-C/EBP complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RNA polymerase II transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of protein-DNA complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA damage-inducible transcript 3 protein
    Names
    C/EBP homoologous protein 10
    C/EBP zeta
    CCAAT/enhancer-binding protein homologous protein
    DDIT-3
    alternative DDIT3 proteins
    c/EBP-homologous protein 10
    growth arrest and DNA-damage-inducible protein GADD153

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290183.2NP_001277112.1  DNA damage-inducible transcript 3 protein

      See identical proteins and their annotated locations for NP_001277112.1

      Status: VALIDATED

      Source sequence(s)
      AC144852
      Consensus CDS
      CCDS24236.1
      UniProtKB/Swiss-Prot
      P35639, Q91YW9
      UniProtKB/TrEMBL
      Q3V405
      Related
      ENSMUSP00000118339.2, ENSMUST00000139091.2
      Conserved Domains (2) summary
      smart00338
      Location:100160
      BRLZ; basic region leucin zipper
      cd14686
      Location:102152
      bZIP; coiled coil [structural motif]
    2. NM_001428453.1NP_001415382.1  DNA damage-inducible transcript 3 protein

      Status: VALIDATED

      Source sequence(s)
      AC144852
      UniProtKB/Swiss-Prot
      P35639, Q91YW9
      UniProtKB/TrEMBL
      Q3V405
    3. NM_001428454.1NP_001415383.1  DNA damage-inducible transcript 3 protein

      Status: VALIDATED

      Source sequence(s)
      AC144852
      UniProtKB/Swiss-Prot
      P35639, Q91YW9
      UniProtKB/TrEMBL
      Q3V405
    4. NM_007837.5NP_031863.3  DNA damage-inducible transcript 3 protein

      See identical proteins and their annotated locations for NP_031863.3

      Status: VALIDATED

      Source sequence(s)
      AC144852
      Consensus CDS
      CCDS24236.1
      UniProtKB/Swiss-Prot
      P35639, Q91YW9
      UniProtKB/TrEMBL
      Q3V405
      Related
      ENSMUSP00000026475.9, ENSMUST00000026475.15
      Conserved Domains (2) summary
      smart00338
      Location:100160
      BRLZ; basic region leucin zipper
      cd14686
      Location:102152
      bZIP; coiled coil [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127126662..127132160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513197.4XP_006513260.1  DNA damage-inducible transcript 3 protein isoform X2

      Conserved Domains (2) summary
      smart00338
      Location:100160
      BRLZ; basic region leucin zipper
      cd14686
      Location:102152
      bZIP; coiled coil [structural motif]
    2. XM_030244867.1XP_030100727.1  DNA damage-inducible transcript 3 protein isoform X1

      UniProtKB/TrEMBL
      Q3V405
      Conserved Domains (2) summary
      smart00338
      Location:114174
      BRLZ; basic region leucin zipper
      cd14686
      Location:116166
      bZIP; coiled coil [structural motif]