Klhl4 kelch-like 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klhl4provided by MGI
Official Full Name: kelch-like 4provided by MGI
Primary source: MGI:MGI:2442829
See related: Ensembl:ENSMUSG00000025597 AllianceGenome:MGI:2442829
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B130014A11; C130018J01Rik
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in centriolar satellite. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in genitourinary system and heart ventricle. Orthologous to human KLHL4 (kelch like family member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in cerebellum adult (RPKM 4.2), cortex adult (RPKM 2.1) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: X E1; X 49.47 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (113384030..113470826)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (114474333..114561129)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kelch-like protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290477.1 → NP_001277406.1 kelch-like protein 4 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AK081937, AK085099, BX005189

Consensus CDS

CCDS72423.1

UniProtKB/TrEMBL

B1AZQ9, Q6PGA3

Related

ENSMUSP00000108998.2, ENSMUST00000113371.8

Conserved Domains (6) summary

smart00612
Location:564 → 610

Kelch; Kelch domain

PHA03098
Location:175 → 691

PHA03098; kelch-like protein; Provisional

sd00038
Location:459 → 502

Kelch; KELCH repeat [structural motif]

pfam00651
Location:171 → 275

BTB; BTB/POZ domain

pfam01344
Location:458 → 503

Kelch_1; Kelch motif

pfam07707
Location:283 → 382

BACK; BTB And C-terminal Kelch
NM_001290478.1 → NP_001277407.1 kelch-like protein 4 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses two alternate in-frame splice sites, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AK044930, AK081937, AK085099, BX005189

UniProtKB/TrEMBL

Q8BLJ6

Related

ENSMUSP00000118072.2, ENSMUST00000133447.2

Conserved Domains (2) summary

PHA03098
Location:175 → 664

PHA03098; kelch-like protein; Provisional

sd00038
Location:432 → 475

Kelch; KELCH repeat [structural motif]
NM_172781.2 → NP_766369.2 kelch-like protein 4 isoform 1

See identical proteins and their annotated locations for NP_766369.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK081448, AK081937, BX005189

Consensus CDS

CCDS41108.2

UniProtKB/TrEMBL

B1AZR0, Q6PGA3

Related

ENSMUSP00000038080.6, ENSMUST00000040504.12

Conserved Domains (6) summary

smart00612
Location:570 → 616

Kelch; Kelch domain

PHA03098
Location:175 → 697

PHA03098; kelch-like protein; Provisional

sd00038
Location:465 → 508

Kelch; KELCH repeat [structural motif]

pfam00651
Location:171 → 275

BTB; BTB/POZ domain

pfam01344
Location:464 → 509

Kelch_1; Kelch motif

pfam07707
Location:283 → 382

BACK; BTB And C-terminal Kelch