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    Cenph centromere protein H [ Mus musculus (house mouse) ]

    Gene ID: 26886, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cenphprovided by MGI
    Official Full Name
    centromere protein Hprovided by MGI
    Primary source
    MGI:MGI:1349448
    See related
    Ensembl:ENSMUSG00000045273 AllianceGenome:MGI:1349448
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ENP; CENP-H; 1700021I11Rik; 2410018A12Rik; 2610042E16Rik; 2810046K12Rik
    Summary
    Enables kinetochore binding activity. Predicted to be involved in chromosome segregation and mitotic spindle organization. Predicted to act upstream of or within mitotic cell cycle. Located in kinetochore and nucleus. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and skin. Orthologous to human CENPH (centromere protein H). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E14 (RPKM 15.8), CNS E11.5 (RPKM 12.8) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cenph in Genome Data Viewer
    Location:
    13 53.23 cM; 13 D1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100896187..100912415, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100759674..100775903, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 125 Neighboring gene cyclin dependent kinase 7 Neighboring gene STARR-seq mESC enhancer starr_35477 Neighboring gene STARR-positive B cell enhancer ABC_E7269 Neighboring gene STARR-positive B cell enhancer mm9_chr13:101513935-101514236 Neighboring gene mitochondrial ribosomal protein S36 Neighboring gene STARR-positive B cell enhancer ABC_E1886 Neighboring gene STARR-seq mESC enhancer starr_35481 Neighboring gene cyclin B1 Neighboring gene solute carrier family 30 (zinc transporter), member 5 Neighboring gene STARR-positive B cell enhancer ABC_E4088

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CenpH regulates meiotic G2/M transition by modulating the APC/CCdh1-cyclin B1 pathway in oocytes. Zhang T, et al. Development, 2017 Jan 15. PMID 27993978, Free PMC Article
    2. Characterization of a novel kinetochore protein, CENP-H. Sugata N, et al. J Biol Chem, 1999 Sep 24. PMID 10488063
    3. CENP-H, a constitutive centromere component, is required for centromere targeting of CENP-C in vertebrate cells. Fukagawa T, et al. EMBO J, 2001 Aug 15. PMID 11500386, Free PMC Article
    4. Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes. Sugata N, et al. Hum Mol Genet, 2000 Nov 22. PMID 11092768
    5. Assignment of the centromere protein H (Cenph) gene to mouse chromosome band 13D1 by in situ hybridization and interspecific backcross analyses. Lo AW, et al. Cytogenet Cell Genet, 2000. PMID 11060445

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel role of CenpH in regulating meiotic G2/M transition by acting via the APC/C(Cdh1)-cyclin B1 pathway.
      Title: CenpH regulates meiotic G2/M transition by modulating the APC/CCdh1-cyclin B1 pathway in oocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinetochore binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinetochore binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinetochore binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in kinetochore assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kinetochore organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of inner kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centromere protein H
    Names
    centromere autoantigen H

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399528.1 → NP_001386457.1  centromere protein H isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC112701
      Conserved Domains (1) summary
      PHA02562
      Location:26 → 155
      46; endonuclease subunit; Provisional

    2. NM_021886.3 → NP_068686.1  centromere protein H isoform 1

      See identical proteins and their annotated locations for NP_068686.1

      Status: VALIDATED

      Source sequence(s)
      AC112701
      Consensus CDS
      CCDS26738.1
      UniProtKB/Swiss-Prot
      Q8R3K9, Q9D079, Q9D0N1, Q9QYM8
      Related
      ENSMUSP00000074988.4, ENSMUST00000075550.4
      Conserved Domains (1) summary
      pfam05837
      Location:134 → 233
      CENP-H; Centromere protein H (CENP-H)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      100896187..100912415 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247278.2 → XP_030103138.1  centromere protein H isoform X1

      Conserved Domains (2) summary
      PHA02562
      Location:26 → 113
      46; endonuclease subunit; Provisional
      pfam05837
      Location:136 → 157
      CENP-H; Centromere protein H (CENP-H)

    2. XM_030247280.1 → XP_030103140.1  centromere protein H isoform X3

      Conserved Domains (1) summary
      pfam05837
      Location:33 → 142
      CENP-H; Centromere protein H (CENP-H)

    3. XM_006517678.4 → XP_006517741.1  centromere protein H isoform X3

      See identical proteins and their annotated locations for XP_006517741.1

      Conserved Domains (1) summary
      pfam05837
      Location:33 → 142
      CENP-H; Centromere protein H (CENP-H)

    4. XM_036158055.1 → XP_036013948.1  centromere protein H isoform X3

      Conserved Domains (1) summary
      pfam05837
      Location:33 → 142
      CENP-H; Centromere protein H (CENP-H)

    5. XM_036158056.1 → XP_036013949.1  centromere protein H isoform X3

      Conserved Domains (1) summary
      pfam05837
      Location:33 → 142
      CENP-H; Centromere protein H (CENP-H)

    RNA

    1. XR_003950454.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYM8.1 GenPept UniProtKB/Swiss-Prot:Q9QYM8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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