Gins4 GINS complex subunit 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gins4provided by MGI
Official Full Name: GINS complex subunit 4provided by MGI
Primary source: MGI:MGI:1923847
See related: Ensembl:ENSMUSG00000031546 AllianceGenome:MGI:1923847
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sld5; 2810037C03Rik; 4933405K01Rik
Summary: Acts upstream of or within inner cell mass cell proliferation. Located in cytoplasm and nucleus. Is expressed in several structures, including 4-cell stage embryo; bone marrow; brain; genitourinary system; and inner cell mass. Orthologous to human GINS4 (GINS complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 22.2), liver E14 (RPKM 21.2) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A2; 8 11.42 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (23716626..23727684, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (23226610..23237668, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Influenza virus matrix protein M1 interacts with SLD5 to block host cell cycle.
Title: Influenza virus matrix protein M1 interacts with SLD5 to block host cell cycle.
Attenuation of SLD5 expression results in marked DNA damage in both normal cells and cancer cells, suggesting that it protects against DNA damage.
Title: DNA damage enhanced by the attenuation of SLD5 delays cell cycle restoration in normal cells but not in cancer cells.
Requirement of SLD5 for early embryogenesis.
Title: Requirement of SLD5 for early embryogenesis.
These data suggest that PSF1 and SLD5 may cooperate in the proliferation of immature cell populations.
Title: Identification and characterization of mouse PSF1-binding protein, SLD5.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA unwinding involved in DNA replication	ISO Inferred from Sequence Orthology more info
involved_in DNA unwinding involved in DNA replication	NAS Non-traceable Author Statement more info	PubMed
involved_in double-strand break repair via break-induced replication	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inner cell mass cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CMG complex	ISO Inferred from Sequence Orthology more info
part_of CMG complex	ISS Inferred from Sequence or Structural Similarity more info
part_of GINS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GINS complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: DNA replication complex GINS protein SLD5

Names: GINS complex subunit 4 (Sld5 homolog)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024240.6 → NP_077202.1 DNA replication complex GINS protein SLD5

See identical proteins and their annotated locations for NP_077202.1

Status: VALIDATED

Source sequence(s)

AK076104, BB750165, BG342391, BY309805

Consensus CDS

CCDS22190.1

UniProtKB/Swiss-Prot

Q3TP06, Q99LZ3

Related

ENSMUSP00000033950.6, ENSMUST00000033950.7

Conserved Domains (3) summary

cd11711
Location:26 → 146

GINS_A_Sld5; Alpha-helical domain of GINS complex protein Sld5

COG5086
Location:23 → 223

COG5086; Uncharacterized conserved protein [Function unknown]

pfam16922
Location:165 → 223

SLD5_C; DNA replication complex GINS protein SLD5 C-terminus