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    Rhox4a reproductive homeobox 4A [ Mus musculus (house mouse) ]

    Gene ID: 664609, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rhox4aprovided by MGI
    Official Full Name
    reproductive homeobox 4Aprovided by MGI
    Primary source
    MGI:MGI:3580240
    See related
    Ensembl:ENSMUSG00000079639 AllianceGenome:MGI:3580240
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rhox4; Rhox4.1
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: This gene was previously named "Rhox4" by MacLean, et. al. Genesis (2006) 44:122 (PubMed ID: 16496311) and "Rhox4.1" by Morris, et. al. Mamm. Genome (2006) 17:178 (PubMed ID: 16465597). Its official nomenclature is now Rhox4a. [07 Jan 2013]
    Expression
    Biased expression in placenta adult (RPKM 3.5), thymus adult (RPKM 0.4) and 2 other tissues See more
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    Genomic context

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    See Rhox4a in Genome Data Viewer
    Location:
    X A3.3; X 21.69 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (36528709..36533789)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (37265067..37270136)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene reproductive homeobox 2A Neighboring gene reproductive homeobox 3A Neighboring gene reproductive homeobox 3A2 Neighboring gene reproductive homeobox 4A2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The rhox homeobox gene family shows sexually dimorphic and dynamic expression during mouse embryonic gonad development. Daggag H, et al. Biol Reprod, 2008 Sep. PMID 18562707
    2. Rhox homeobox gene cluster: recent duplication of three family members. MacLean JA 2nd, et al. Genesis, 2006 Mar. PMID 16496311
    3. Identification of a tandem duplicated array in the Rhox alpha locus on mouse chromosome X. Morris L, et al. Mamm Genome, 2006 Feb. PMID 16465597
    4. Rhox: a new homeobox gene cluster. Maclean JA 2nd, et al. Cell, 2005 Feb 11. PMID 15707895
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    reproductive homeobox 4A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039688.3 → NP_001034777.1  reproductive homeobox 4A

      See identical proteins and their annotated locations for NP_001034777.1

      Status: VALIDATED

      Source sequence(s)
      AJ972665
      Consensus CDS
      CCDS40930.1
      UniProtKB/TrEMBL
      B7ZWB1, Q9D3I8
      Related
      ENSMUSP00000110848.4, ENSMUST00000115194.5
      Conserved Domains (2) summary
      cd00086
      Location:129 → 187
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      cl38985
      Location:41 → 126
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      36528709..36533789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541392.4 → XP_006541455.1  reproductive homeobox 4A isoform X1

      See identical proteins and their annotated locations for XP_006541455.1

      UniProtKB/TrEMBL
      B7ZWB1
      Conserved Domains (2) summary
      cd00086
      Location:129 → 186
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      cl38985
      Location:41 → 126
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_006541393.3 → XP_006541456.1  reproductive homeobox 4A isoform X2

      See identical proteins and their annotated locations for XP_006541456.1

      UniProtKB/TrEMBL
      B7ZWB1
      Conserved Domains (1) summary
      cl38985
      Location:41 → 126
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

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