U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tmem59 transmembrane protein 59 [ Mus musculus (house mouse) ]

    Gene ID: 56374, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmem59provided by MGI
    Official Full Name
    transmembrane protein 59provided by MGI
    Primary source
    MGI:MGI:1929278
    See related
    Ensembl:ENSMUSG00000028618 AllianceGenome:MGI:1929278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ORF18; MTDCF1; D4Ertd20e; 1110001M20Rik; 3110046P06Rik
    Summary
    Enables endopeptidase activity. Predicted to be involved in negative regulation of protein localization to plasma membrane and positive regulation of autophagy. Predicted to act upstream of or within with a negative effect on protein glycosylation. Predicted to be located in Golgi cis cisterna; Golgi medial cisterna; and Golgi trans cisterna. Predicted to be active in late endosome and lysosome. Is expressed in several structures, including alveolar sulcus; central nervous system; olfactory epithelium; retina; and skeleton. Orthologous to human TMEM59 (transmembrane protein 59). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 174.0), colon adult (RPKM 122.1) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tmem59 in Genome Data Viewer
    Location:
    4 C7; 4 50.12 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (107035827..107058193)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (107178630..107200996)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CUB domain containing protein 2 Neighboring gene predicted gene 12802 Neighboring gene transcription elongation factor A (SII) N-terminal and central domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E4641 Neighboring gene low density lipoprotein receptor class A domain containing 1 Neighboring gene leucine rich repeat containing 42 Neighboring gene STARR-positive B cell enhancer ABC_E4642

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within_negative_effect protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi cis cisterna IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi cis cisterna ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi medial cisterna IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi medial cisterna ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi trans cisterna IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi trans cisterna ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    transmembrane protein 59
    Names
    thymic dendritic cell-derived factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029565.3NP_083841.4  transmembrane protein 59 precursor

      See identical proteins and their annotated locations for NP_083841.4

      Status: VALIDATED

      Source sequence(s)
      AK145644, BB860994, BC058273
      Consensus CDS
      CCDS18432.1
      UniProtKB/Swiss-Prot
      Q3TWB4, Q99LY8, Q9D1P9, Q9QY73
      Related
      ENSMUSP00000030361.5, ENSMUST00000030361.11
      Conserved Domains (1) summary
      pfam12280
      Location:72256
      BSMAP; Brain specific membrane anchored protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      107035827..107058193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)