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    Impa1 inositol (myo)-1(or 4)-monophosphatase 1 [ Mus musculus (house mouse) ]

    Gene ID: 55980, updated on 3-Dec-2024

    Summary

    Official Symbol
    Impa1provided by MGI
    Official Full Name
    inositol (myo)-1(or 4)-monophosphatase 1provided by MGI
    Primary source
    MGI:MGI:1933158
    See related
    Ensembl:ENSMUSG00000027531 AllianceGenome:MGI:1933158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610002K09Rik; 2900059K10Rik
    Summary
    Enables magnesium ion binding activity. Predicted to be involved in inositol metabolic process; phosphatidylinositol biosynthetic process; and signal transduction. Predicted to be located in axon; cytoplasm; and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 59 and intellectual disability. Orthologous to human IMPA1 (inositol monophosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 9.6), cerebellum adult (RPKM 9.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Impa1 in Genome Data Viewer
    Location:
    3 A1; 3 2.61 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (10377016..10396499, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (10311956..10331439, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene fatty acid binding protein 4, adipocyte Neighboring gene STARR-seq mESC enhancer starr_06936 Neighboring gene STARR-positive B cell enhancer ABC_E10175 Neighboring gene fatty acid binding protein 12 Neighboring gene STARR-seq mESC enhancer starr_06939 Neighboring gene predicted gene, 37316 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 5 Neighboring gene STARR-positive B cell enhancer ABC_E7900 Neighboring gene STARR-positive B cell enhancer mm9_chr3:10351257-10351557 Neighboring gene zinc finger, AN1-type domain 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables inositol monophosphate 1-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables inositol monophosphate 1-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables inositol monophosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables inositol monophosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables lithium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lithium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables manganese ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in inositol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within inositol metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in phosphate-containing compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    inositol monophosphatase 1
    Names
    D-galactose 1-phosphate phosphatase
    IMP 1
    IMPase 1
    inositol-1(or 4)-monophosphatase 1
    lithium-sensitive myo-inositol monophosphatase A1
    myo-inositol monophosphatase 1
    NP_001297362.1
    NP_061352.2
    XP_006530140.1
    XP_006530141.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310433.2NP_001297362.1  inositol monophosphatase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC123726
      Consensus CDS
      CCDS79884.1
      UniProtKB/TrEMBL
      A0A0A6YW07
      Related
      ENSMUSP00000141345.2, ENSMUST00000191670.6
      Conserved Domains (1) summary
      cd01639
      Location:8164
      IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...
    2. NM_001428861.1NP_001415790.1  inositol monophosphatase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123726
      UniProtKB/TrEMBL
      Q3TME6, Q3U5R8, Q9D066
    3. NM_001428862.1NP_001415791.1  inositol monophosphatase 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC123726
    4. NM_001428863.1NP_001415792.1  inositol monophosphatase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC123726
      UniProtKB/TrEMBL
      Q3TME6, Q3U5R8, Q924B0, Q9D066
    5. NM_018864.7NP_061352.2  inositol monophosphatase 1 isoform 1

      See identical proteins and their annotated locations for NP_061352.2

      Status: VALIDATED

      Source sequence(s)
      AC123726
      Consensus CDS
      CCDS17240.1
      UniProtKB/TrEMBL
      Q3TME6, Q3U5R8, Q924B0, Q9D066
      Related
      ENSMUSP00000068174.9, ENSMUST00000065938.15
      Conserved Domains (1) summary
      cd01639
      Location:8254
      IMPase; inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      10377016..10396499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530077.4XP_006530140.1  inositol monophosphatase 1 isoform X1

      Conserved Domains (1) summary
      cd01639
      Location:61307
      IMPase; inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled ...
    2. XM_006530078.5XP_006530141.1  inositol monophosphatase 1 isoform X2

      Conserved Domains (1) summary
      cd01639
      Location:61217
      IMPase; inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled ...