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    Igfbp5 insulin-like growth factor binding protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 16011, updated on 9-Dec-2024

    Summary

    Official Symbol
    Igfbp5provided by MGI
    Official Full Name
    insulin-like growth factor binding protein 5provided by MGI
    Primary source
    MGI:MGI:96440
    See related
    Ensembl:ENSMUSG00000026185 AllianceGenome:MGI:96440
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IGFBP-5; IGFBP-5P
    Summary
    Enables fibronectin binding activity and insulin-like growth factor binding activity. Involved in several processes, including lung alveolus development; negative regulation of skeletal muscle hypertrophy; and osteoblast differentiation. Acts upstream of or within several processes, including hair follicle morphogenesis; negative regulation of osteoblast differentiation; and regulation of insulin-like growth factor receptor signaling pathway. Predicted to be located in cytoplasm and nucleus. Predicted to be part of insulin-like growth factor ternary complex. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; embryo ectoderm; heart and pericardium; limb; and metanephros. Orthologous to human IGFBP5 (insulin like growth factor binding protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 121.4), kidney adult (RPKM 105.9) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Igfbp5 in Genome Data Viewer
    Location:
    1 C3; 1 36.94 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (72897224..72914024, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (72858065..72874865, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30788 Neighboring gene predicted gene, 30847 Neighboring gene STARR-seq mESC enhancer starr_01288 Neighboring gene STARR-seq mESC enhancer starr_01290 Neighboring gene insulin-like growth factor binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_01295 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 31047

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fibronectin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fibronectin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables insulin-like growth factor I binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables insulin-like growth factor I binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables insulin-like growth factor I binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables insulin-like growth factor II binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables insulin-like growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables insulin-like growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor ligand activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cAMP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in female pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glucose homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hair follicle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of insulin-like growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mammary gland involution IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of insulin-like growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of insulin-like growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of osteoblast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of skeletal muscle hypertrophy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in osteoblast differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of insulin-like growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of insulin-like growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of insulin-like growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to growth hormone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within striated muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within striated muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within type B pancreatic cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of insulin-like growth factor binding protein complex IC
    Inferred by Curator
    more info
    PubMed 
    part_of insulin-like growth factor ternary complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of insulin-like growth factor ternary complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of insulin-like growth factor ternary complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    insulin-like growth factor-binding protein 5
    Names
    IBP-5
    IGF-binding protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010518.2NP_034648.2  insulin-like growth factor-binding protein 5 precursor

      See identical proteins and their annotated locations for NP_034648.2

      Status: VALIDATED

      Source sequence(s)
      BC018579, BC029321, BC057447
      Consensus CDS
      CCDS15037.1
      UniProtKB/Swiss-Prot
      Q07079
      UniProtKB/TrEMBL
      Q3UQV0
      Related
      ENSMUSP00000027377.9, ENSMUST00000027377.9
      Conserved Domains (2) summary
      smart00121
      Location:24100
      IB; Insulin growth factor-binding protein homologues
      pfam00086
      Location:191262
      Thyroglobulin_1; Thyroglobulin type-1 repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      72897224..72914024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)