Csn1s2a casein alpha s2-like A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Csn1s2aprovided by MGI
Official Full Name: casein alpha s2-like Aprovided by MGI
Primary source: MGI:MGI:88542
See related: Ensembl:ENSMUSG00000061937 AllianceGenome:MGI:88542
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Csng; PP22
Summary: Predicted to enable protein homodimerization activity and zymogen binding activity. Located in extracellular region. Is expressed in jaw bone; nervous system; sensory organ; and thoracic segment skeleton. Orthologous to human CSN1S2AP (casein alpha s2 like A, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 5 E1; 5 43.56 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (87922309..87936657)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (87774450..87788798)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

promoter is active in lactating mammary tissue; can be induced synergistically by glucocorticoids and prolactin; regulation of the promoter was analysed in cell culture models and compared to the regulaton of the beta casein promoter
Title: Structure and regulation of the murine gamma-casein gene.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein homodimerization activity	IBA Inferred from Biological aspect of Ancestor more info
enables zymogen binding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alpha-S2-casein-like A

Names: gamma casein; milk protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001304765.1 → NP_001291694.1 alpha-S2-casein-like A isoform 2 precursor

See identical proteins and their annotated locations for NP_001291694.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AC074046, AK164738, BB661763

Consensus CDS

CCDS80318.1

UniProtKB/TrEMBL

Q3TP41

Related

ENSMUSP00000143715.2, ENSMUST00000196749.5
NM_001304767.1 → NP_001291696.1 alpha-S2-casein-like A isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

AC074046, AK142688, BB661763

Consensus CDS

CCDS84901.1

UniProtKB/TrEMBL

A0A0G2JET6

Related

ENSMUSP00000142901.2, ENSMUST00000200322.5
NM_001304768.1 → NP_001291697.1 alpha-S2-casein-like A isoform 5 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 5), compared to isoform 1.

Source sequence(s)

AC074046, AK142688, BB661763

Consensus CDS

CCDS84900.1

UniProtKB/TrEMBL

A0A0G2JGC6

Related

ENSMUSP00000143515.2, ENSMUST00000196585.2
NM_001304769.1 → NP_001291698.1 alpha-S2-casein-like A isoform 4 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.

Source sequence(s)

AC074046, AK142688, BB661763

UniProtKB/TrEMBL

Q547D1
NM_007785.2 → NP_031811.1 alpha-S2-casein-like A isoform 1 precursor

See identical proteins and their annotated locations for NP_031811.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC074046, AK142688, BB661763

Consensus CDS

CCDS39132.1

UniProtKB/Swiss-Prot

Q02862

UniProtKB/TrEMBL

Q547D1

Related

ENSMUSP00000075716.4, ENSMUST00000076379.8