U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pgam2 phosphoglycerate mutase 2 [ Mus musculus (house mouse) ]

    Gene ID: 56012, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pgam2provided by MGI
    Official Full Name
    phosphoglycerate mutase 2provided by MGI
    Primary source
    MGI:MGI:1933118
    See related
    Ensembl:ENSMUSG00000020475 AllianceGenome:MGI:1933118
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables phosphoglycerate mutase activity. Involved in canonical glycolysis. Acts upstream of or within Notch signaling pathway and glycolytic process. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb mesenchyme; and sensory organ. Human ortholog(s) of this gene implicated in myoglobinuria. Orthologous to human PGAM2 (phosphoglycerate mutase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 618.6), heart adult (RPKM 314.4) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pgam2 in Genome Data Viewer
    Location:
    11 A1; 11 3.87 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (5751637..5753796, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (5801637..5803796, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene upregulator of cell proliferation Neighboring gene STARR-seq mESC enhancer starr_28441 Neighboring gene STARR-positive B cell enhancer ABC_E8385 Neighboring gene ubiquitin-conjugating enzyme E2D, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6945 Neighboring gene STARR-seq mESC enhancer starr_28442 Neighboring gene drebrin-like Neighboring gene STARR-positive B cell enhancer ABC_E9815 Neighboring gene STARR-seq mESC enhancer starr_28443 Neighboring gene polymerase (DNA directed), mu Neighboring gene AE binding protein 1 Neighboring gene polymerase (DNA directed), delta 2, regulatory subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables bisphosphoglycerate mutase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoglycerate mutase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphoglycerate mutase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in canonical glycolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glycolytic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to mercury ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to mercury ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in striated muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in striated muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    phosphoglycerate mutase 2
    Names
    BPG-dependent PGAM 2
    PGAM-M
    muscle-specific phosphoglycerate mutase
    phosphoglycerate mutase isozyme M
    phosphoglycerate mutase muscle-specific subunit
    NP_061358.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018870.3NP_061358.1  phosphoglycerate mutase 2

      See identical proteins and their annotated locations for NP_061358.1

      Status: VALIDATED

      Source sequence(s)
      AK169019, AV041299, BE650074
      Consensus CDS
      CCDS24404.1
      UniProtKB/Swiss-Prot
      O70250
      UniProtKB/TrEMBL
      Q5NCI4
      Related
      ENSMUSP00000020768.4, ENSMUST00000020768.4
      Conserved Domains (1) summary
      TIGR01258
      Location:4251
      pgm_1; phosphoglycerate mutase, BPG-dependent, family 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      5751637..5753796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)