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    Gosr2 golgi SNAP receptor complex member 2 [ Mus musculus (house mouse) ]

    Gene ID: 56494, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gosr2provided by MGI
    Official Full Name
    golgi SNAP receptor complex member 2provided by MGI
    Primary source
    MGI:MGI:1927204
    See related
    Ensembl:ENSMUSG00000020946 AllianceGenome:MGI:1927204
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gs27; SNARE; membrin; 2310032N09Rik
    Summary
    Predicted to enable SNAP receptor activity and SNARE binding activity. Acts upstream of or within vesicle-mediated transport. Located in Golgi membrane and endoplasmic reticulum membrane. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut gland; and respiratory system. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 6. Orthologous to human GOSR2 (golgi SNAP receptor complex member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 36.5), genital fat pad adult (RPKM 36.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gosr2 in Genome Data Viewer
    Location:
    11 E1; 11 67.43 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (103567675..103590139, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (103676849..103697723, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700072I22 gene Neighboring gene reprimo-like Neighboring gene RIKEN cDNA C130046K22 gene Neighboring gene wingless-type MMTV integration site family, member 9B Neighboring gene STARR-seq mESC enhancer starr_30857 Neighboring gene STARR-seq mESC enhancer starr_30858 Neighboring gene wingless-type MMTV integration site family, member 3 Neighboring gene STARR-seq mESC enhancer starr_30861 Neighboring gene VISTA enhancer mm1102 Neighboring gene N-ethylmaleimide sensitive fusion protein Neighboring gene predicted gene, 35365

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A 29-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (Vti1-rp2) implicated in protein trafficking in the secretory pathway. Xu Y, et al. J Biol Chem, 1998 Aug 21. PMID 9705316
    2. Mutations in Membrin/GOSR2 Reveal Stringent Secretory Pathway Demands of Dendritic Growth and Synaptic Integrity. Praschberger R, et al. Cell Rep, 2017 Oct 3. PMID 28978487, Free PMC Article
    3. A SNARE involved in protein transport through the Golgi apparatus. Lowe SL, et al. Nature, 1997 Oct 23. PMID 9349823
    4. Investigations of the genomic region that contains the clf1 mutation, a causal gene in multifactorial cleft lip and palate in mice. Juriloff DM, et al. Birth Defects Res A Clin Mol Teratol, 2005 Feb. PMID 15690355
    5. Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Hay JC, et al. Cell, 1997 Apr 4. PMID 9094723

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutations in GOSR2 reveal stringent secretory pathway demands of dendritic growth and synaptic integrity.
      Title: Mutations in Membrin/GOSR2 Reveal Stringent Secretory Pathway Demands of Dendritic Growth and Synaptic Integrity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in membrane fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in ER to Golgi transport vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SNARE complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Golgi SNAP receptor complex member 2
    Names
    27 kDa Golgi SNARE protein
    golgi SNARE

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362852.1 → NP_001349781.1  Golgi SNAP receptor complex member 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627252, CA315963
      Conserved Domains (2) summary
      cd15863
      Location:119 → 184
      SNARE_GS27; SNARE motif of GS27
      cl26472
      Location:7 → 106
      DUF3084; Protein of unknown function (DUF3084)

    2. NM_001362853.1 → NP_001349782.1  Golgi SNAP receptor complex member 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL627252
      Conserved Domains (2) summary
      cd15863
      Location:116 → 181
      SNARE_GS27; SNARE motif of GS27
      cl26472
      Location:6 → 103
      DUF3084; Protein of unknown function (DUF3084)

    3. NM_001362854.1 → NP_001349783.1  Golgi SNAP receptor complex member 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL627252
      Conserved Domains (1) summary
      cd15863
      Location:102 → 167
      SNARE_GS27; SNARE motif of GS27

    4. NM_001362855.1 → NP_001349784.1  Golgi SNAP receptor complex member 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL627252
      Conserved Domains (1) summary
      cd15863
      Location:102 → 167
      SNARE_GS27; SNARE motif of GS27

    5. NM_001362856.1 → NP_001349785.1  Golgi SNAP receptor complex member 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL627252
      Conserved Domains (1) summary
      cd15863
      Location:102 → 167
      SNARE_GS27; SNARE motif of GS27

    6. NM_001362857.1 → NP_001349786.1  Golgi SNAP receptor complex member 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL627252
      Conserved Domains (1) summary
      cd15863
      Location:91 → 156
      SNARE_GS27; SNARE motif of GS27

    7. NM_001362858.1 → NP_001349787.1  Golgi SNAP receptor complex member 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL627252, CA316919
      Consensus CDS
      CCDS88267.1
      UniProtKB/TrEMBL
      A2A9I0
      Related
      ENSMUSP00000102627.3, ENSMUST00000107013.3
      Conserved Domains (2) summary
      cl22856
      Location:113 → 138
      SNARE; SNARE motif
      cl25917
      Location:11 → 141
      Exonuc_VII_L; Exonuclease VII, large subunit

    8. NM_001362859.1 → NP_001349788.1  Golgi SNAP receptor complex member 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL627252
      Conserved Domains (1) summary
      cl22856
      Location:95 → 120
      SNARE; SNARE motif

    9. NM_001362860.1 → NP_001349789.1  Golgi SNAP receptor complex member 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL627252
      Conserved Domains (1) summary
      cl22856
      Location:95 → 120
      SNARE; SNARE motif

    10. NM_019650.4 → NP_062624.2  Golgi SNAP receptor complex member 2 isoform 1

      See identical proteins and their annotated locations for NP_062624.2

      Status: VALIDATED

      Source sequence(s)
      AK005697, AL627252
      Consensus CDS
      CCDS25521.1
      UniProtKB/Swiss-Prot
      O35166, Q3UDN0, Q9CR77
      Related
      ENSMUSP00000021329.8, ENSMUST00000021329.14
      Conserved Domains (2) summary
      cd15863
      Location:120 → 185
      SNARE_GS27; SNARE motif of GS27
      cl26472
      Location:7 → 107
      DUF3084; Protein of unknown function (DUF3084)

    RNA

    1. NR_156185.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL627252

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      103567675..103590139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246190.2 → XP_030102050.1  Golgi SNAP receptor complex member 2 isoform X2

      Conserved Domains (2) summary
      PRK00286
      Location:11 → 140
      xseA; exodeoxyribonuclease VII large subunit; Reviewed
      cl22856
      Location:112 → 137
      SNARE; SNARE motif

    2. XM_030246189.1 → XP_030102049.1  Golgi SNAP receptor complex member 2 isoform X1

      Conserved Domains (1) summary
      cd15863
      Location:102 → 167
      SNARE_GS27; SNARE motif of GS27
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35166.2 GenPept UniProtKB/Swiss-Prot:O35166

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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