nhr-8 Nuclear hormone receptor family member nhr-8 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nhr-8
Official Full Name: Nuclear hormone receptor family member nhr-8
Primary source: WormBase:WBGene00003607
Locus tag: CELE_F33D4.1
See related: AllianceGenome:WB:WBGene00003607
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in cholesterol homeostasis. Located in nucleus. Is expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); liver disease (multiple); lung disease (multiple); and melanoma (multiple). Orthologous to human VDR (vitamin D receptor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nhr-8 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 9

Sequence:: Chromosome: IV; NC_003282.8 (7710983..7714210)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pdda is abolished by synthetic ascarosides and steroidal ligands of the nuclear hormone receptor DAF-12. We show that neither ascarosides nor any known steroid hormones are required for Pdda and that another chemical signal mediates this phenotype, in part via the nuclear hormone receptor NHR-8.
Title: Larval crowding accelerates C. elegans development and reduces lifespan.
Dafachronic acid signaling through NHR-8 is essential for diet restriction-mediated longevity.
Title: Steroid hormone signalling links reproduction to lifespan in dietary-restricted Caenorhabditis elegans.
Knockdown of the NHR-8 nuclear receptor enhanced sensitivity to the lipid-reducing activity of alkaloids in Caenorhabditis elegans.
Title: Knockdown of the NHR-8 nuclear receptor enhanced sensitivity to the lipid-reducing activity of alkaloids in Caenorhabditis elegans.
C. elegans NHR-8 NR, a homolog of vertebrate liver X and vitamin D receptors, regulates nematode cholesterol balance, fatty acid desaturation, apolipoprotein production, and bile acid metabolism.
Title: The NHR-8 nuclear receptor regulates cholesterol and bile acid homeostasis in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F33D4.1 (e-PCR)
- UniSTS:310092

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear hormone receptor family member nhr-8

NP_001023169.1

Confirmed by transcript evidence

NP_741445.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

7710983..7714210

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171382.5 → NP_741445.1 Nuclear hormone receptor family member nhr-8 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741445.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O44188, Q8MXI8, Q9XYB7

Conserved Domains (2) summary

cd06929
Location:361 → 541

NR_LBD_F1; Ligand-binding domain of nuclear receptor family 1

cd06966
Location:24 → 117

NR_DBD_CAR; DNA-binding domain of constitutive androstane receptor (CAR) is composed of two C4-type zinc fingers
NM_001027998.6 → NP_001023169.1 Nuclear hormone receptor family member nhr-8 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023169.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XYB7

Conserved Domains (2) summary

cd06929
Location:360 → 540

NR_LBD_F1; Ligand-binding domain of nuclear receptor family 1

cd06966
Location:24 → 117

NR_DBD_CAR; DNA-binding domain of constitutive androstane receptor (CAR) is composed of two C4-type zinc fingers