U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    pag-3 Zinc finger protein GFI1 homolog pag-3 [ Caenorhabditis elegans ]

    Gene ID: 181588, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    pag-3
    Official Full Name
    Zinc finger protein GFI1 homolog pag-3
    Primary source
    WormBase:WBGene00003909
    Locus tag
    CELE_F45B8.4
    See related
    AllianceGenome:WB:WBGene00003909
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription corepressor activity; and transcription corepressor binding activity. Involved in several processes, including negative regulation of secretion by cell; negative regulation of transcription by RNA polymerase II; and neuroblast fate specification. Located in nucleus. Is expressed in several structures, including P1.aap; P11.aaap; P12.aaap; anal region; and neurons. Used to study alcohol use disorder. Orthologous to human ZNF683 (zinc finger protein 683). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See pag-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (14950752..14954648, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Multidrug resistance-associated protein 5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Conservation of sequence and function of the pag-3 genes from C. elegans and C. briggsae. Aamodt E, et al. Gene, 2000 Feb 8. PMID 10675614
    2. High copy arrays containing a sequence upstream of mec-3 alter cell migration and axonal morphology in C. elegans. Toms N, et al. BMC Dev Biol, 2001. PMID 11182881, Free PMC Article
    3. The Caenorhabditis elegans protein CTBP-1 defines a new group of THAP domain-containing CtBP corepressors. Nicholas HR, et al. J Mol Biol, 2008 Jan 4. PMID 18005989
    4. A C. elegans mutant screen based on antibody or histochemical staining. Xie G, et al. Genet Anal, 1995 Oct. PMID 8574900
    5. unc-3-dependent repression of specific motor neuron fates in Caenorhabditis elegans. Prasad B, et al. Dev Biol, 2008 Nov 15. PMID 18817768, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of PAG-3 results in up-regulation of IDA-1 and other dense core vesicle proteins.
      Title: Loss of the transcriptional repressor PAG-3/Gfi-1 results in enhanced neurosecretion that is dependent on the dense-core vesicle membrane protein IDA-1/IA-2.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription corepressor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of backward locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of forward locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Zinc finger protein GFI1 homolog pag-3
    NP_510480.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14950752..14954648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078079.6 → NP_510480.1  Zinc finger protein GFI1 homolog pag-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510480.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EDE1
      Conserved Domains (4) summary
      COG5048
      Location:164 → 233
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:156 → 176
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:154 → 176
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:196 → 221
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools