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    mxt-1 Eukaryotic translation initiation factor 4E-binding protein Mextli homolog [ Caenorhabditis elegans ]

    Gene ID: 173151, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mxt-1
    Official Full Name
    Eukaryotic translation initiation factor 4E-binding protein Mextli homolog
    Primary source
    WormBase:WBGene00012478
    Locus tag
    CELE_Y18D10A.8
    See related
    AllianceGenome:WB:WBGene00012478
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable eukaryotic initiation factor 4E binding activity and translation initiation factor activity. Predicted to be involved in positive regulation of translation and regulation of formation of translation initiation ternary complex. Predicted to be part of RNA cap binding activity complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mxt-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (12844269..12853130)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Sodium/hydrogen exchanger Neighboring gene ncRNA Neighboring gene SSD domain-containing protein Neighboring gene putative cytosolic iron-sulfur protein assembly protein CIAO1 homolog Neighboring gene C-type lectin domain-containing protein Neighboring gene Dynein regulatory complex subunit 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mextli proteins use both canonical bipartite and novel tripartite binding modes to form eIF4E complexes that display differential sensitivity to 4E-BP regulation. Peter D, et al. Genes Dev, 2015 Sep 1. PMID 26294658, Free PMC Article
    2. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article
    3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic initiation factor 4E binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables eukaryotic initiation factor 4E binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of formation of translation initiation ternary complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA cap binding complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Eukaryotic translation initiation factor 4E-binding protein Mextli homolog
    NP_493246.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      12844269..12853130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060845.6 → NP_493246.1  Eukaryotic translation initiation factor 4E-binding protein Mextli homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493246.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XW13
      Conserved Domains (1) summary
      cd00105
      Location:246 → 307
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XW13.1

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