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    • Showing Current items.

    mus-101 BRCT domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172929, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mus-101
    Official Full Name
    BRCT domain-containing protein
    Primary source
    WormBase:WBGene00009507
    Locus tag
    CELE_F37D6.1
    See related
    AllianceGenome:WB:WBGene00009507
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including DNA damage response; DNA-templated DNA replication; and germ cell proliferation. Predicted to be located in nucleus. Orthologous to human TOPBP1 (DNA topoisomerase II binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mus-101 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    17
    Sequence:
    Chromosome: I; NC_003279.8 (10479305..10484969, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene SKA complex subunit 1 Neighboring gene Dynein light chain Neighboring gene C2H2-type domain-containing protein Neighboring gene BED-type domain-containing protein Neighboring gene F-box domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Temperature-sensitive zygote defective mutants of Caenorhabditis elegans. Vanderslice R, et al. Dev Biol, 1976 Mar. PMID 943346
    2. Identification of the critical replication targets of CDK reveals direct regulation of replication initiation factors by the embryo polarity machinery in C. elegans. Gaggioli V, et al. PLoS Genet, 2020 Dec. PMID 33320862, Free PMC Article
    3. Alterations of life span in the nematode Caenorhabditis elegans under monoxenic culture conditions. Hosono R, et al. Exp Gerontol, 1989. PMID 2731582
    4. CDK phosphorylation of SLD-2 is required for replication initiation and germline development in C. elegans. Gaggioli V, et al. J Cell Biol, 2014 Feb 17. PMID 24535824, Free PMC Article
    5. Systematic, RNA-interference-mediated identification of mus-101 modifier genes in Caenorhabditis elegans. Holway AH, et al. Genetics, 2005 Mar. PMID 15654100, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of the critical replication targets of CDK reveals direct regulation of replication initiation factors by the embryo polarity machinery in C. elegans.
      Title: Identification of the critical replication targets of CDK reveals direct regulation of replication initiation factors by the embryo polarity machinery in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BRCT domain-containing protein
    NP_492743.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10479305..10484969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060342.9 → NP_492743.3  BRCT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492743.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20129
      Conserved Domains (4) summary
      smart00292
      Location:589 → 659
      BRCT; breast cancer carboxy-terminal domain
      cd00027
      Location:944 → 1016
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      pfam00533
      Location:129 → 204
      BRCT; BRCA1 C Terminus (BRCT) domain
      cl00038
      Location:235 → 297
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    Nucleotide Protein
    Heading Accession and Version

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