rga-1 Rho GTPase-activating protein 68F;Rho-GAP domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rga-1
Official Full Name: Rho GTPase-activating protein 68F;Rho-GAP domain-containing protein
Primary source: WormBase:WBGene00012203
Locus tag: CELE_W02B12.8
See related: AllianceGenome:WB:WBGene00012203
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables GTPase regulator activity. Predicted to be involved in negative regulation of endocytic recycling and small GTPase-mediated signal transduction. Predicted to be active in cytoplasm. Orthologous to several human genes including ARHGAP1 (Rho GTPase activating protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rga-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 9

Sequence:: Chromosome: II; NC_003280.10 (11464894..11468653)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W02B12.8 (e-PCR)
- UniSTS:315136

W02B12.7 (e-PCR)
- UniSTS:311085

W02B12.6 (e-PCR)
- UniSTS:308149

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase regulator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Rho GTPase-activating protein 68F;Rho-GAP domain-containing protein

NP_001022390.1

Confirmed by transcript evidence

NP_001022391.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

11464894..11468653

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027219.6 → NP_001022390.1 Rho GTPase-activating protein 68F [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022390.1

Status: REVIEWED

UniProtKB/TrEMBL

Q23130

Conserved Domains (2) summary

smart00516
Location:74 → 225

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cl02570
Location:242 → 442

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
NM_001027220.5 → NP_001022391.1 Rho-GAP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022391.1

Status: REVIEWED

UniProtKB/TrEMBL

Q58AA5

Conserved Domains (1) summary

cl02570
Location:43 → 243

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...