nhr-25 Nuclear hormone receptor family member nhr-25 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nhr-25
Official Full Name: Nuclear hormone receptor family member nhr-25
Primary source: WormBase:WBGene00003623
Locus tag: CELE_F11C1.6
See related: AllianceGenome:WB:WBGene00003623
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables armadillo repeat domain binding activity. Involved in molting cycle and positive regulation of nematode male tail tip morphogenesis. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including excretory system; gonad; hypodermis; somatic gonad precursor; and vulval precursor cell. Human ortholog(s) of this gene implicated in 46,XX sex reversal 4; 46,XY sex reversal 3; Zellweger syndrome; primary ovarian insufficiency 7; and spermatogenic failure 8. Orthologous to several human genes including NR5A2 (nuclear receptor subfamily 5 group A member 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nhr-25 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 10

Sequence:: Chromosome: X; NC_003284.9 (13008886..13013964)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An environment-microorganism-host metabolic axis regulates host mitochondrial dynamics and lipid metabolism via nhr25/GRL-21/PTR-24 signaling.
Title: Microbial metabolites regulate host lipid metabolism through NR5A-Hedgehog signalling.
these data indicate that inactivation of either acs-3 or nhr-25 causes stress sensitivity and increased expression of innate immunity/stress genes, most likely by different mechanisms.
Title: Defects in the C. elegans acyl-CoA synthase, acs-3, and nuclear hormone receptor, nhr-25, cause sensitivity to distinct, but overlapping stresses.
We conclude that sumoylation operates at multiple levels to affect NHR-25 activity in a highly coordinated spatial and temporal manner
Title: Sumoylated NHR-25/NR5A regulates cell fate during C. elegans vulval development.
Functional validation of a subset of the target genes showed both activating and inhibitory roles of NHR-25 and ELT-3 in regulating their targets.
Title: Collaborative regulation of development but independent control of metabolism by two epidermis-specific transcription factors in Caenorhabditis elegans.
ACS-3-derived long-chain fatty acyl-CoAs, perhaps incorporated into complex ligands such as phosphoinositides, modulate NHR-25 function, which in turn regulates an endocrine program of lipid uptake and synthesis.
Title: Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25.
NHR-25 cooperates with the Wnt/beta-catenin asymmetry pathway to control differentiation of the T seam cell.
Title: The nuclear receptor NHR-25 cooperates with the Wnt/beta-catenin asymmetry pathway to control differentiation of the T seam cell in C. elegans.
NHR-25 knockdown restores DTC formation and fertility in pop-1 and sys-1 mutants, suggesting that a balance between NHR-25 and beta-catenin pathway activities is required to establish both proximal and distal fates.
Title: Crosstalk between a nuclear receptor and beta-catenin signaling decides cell fates in the C. elegans somatic gonad.
Results indicate that nhr-25 plays an integral role in regulating cellular processes of epidermal cells.
Title: The Caenorhabditis elegans nuclear receptor gene nhr-25 regulates epidermal cell development.
mir-84 and let-7 promote exit from the molting cycle by regulating targets in the heterochronic pathway and also nhr-23 and nhr-25, genes encoding conserved nuclear hormone receptors essential for larval molting.
Title: The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F11C1.6 (e-PCR)
- UniSTS:309685

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables armadillo repeat domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in molting cycle, collagen and cuticulin-based cuticle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear hormone receptor family member nhr-25

NP_001024550.1

Confirmed by transcript evidence

NP_001024551.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

13008886..13013964

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029379.5 → NP_001024550.1 Nuclear hormone receptor family member nhr-25 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024550.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19345, Q7JMA3, Q9NJ95, Q9NJ96, Q9NJ97

Conserved Domains (2) summary

cd06930
Location:349 → 501

NR_LBD_F2; Ligand-binding domain of nuclear receptor family 2

cd07167
Location:18 → 110

NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
NM_001029380.8 → NP_001024551.1 Nuclear hormone receptor family member nhr-25 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024551.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19345

Conserved Domains (2) summary

cd06930
Location:269 → 421

NR_LBD_F2; Ligand-binding domain of nuclear receptor family 2

cl02596
Location:1 → 30

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers