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    usp-5 Ubiquitin carboxyl-terminal hydrolase [ Caenorhabditis elegans ]

    Gene ID: 172296, updated on 9-Dec-2024

    Summary

    Official Symbol
    usp-5
    Official Full Name
    Ubiquitin carboxyl-terminal hydrolase
    Primary source
    WormBase:WBGene00020839
    Locus tag
    CELE_T27A3.2
    See related
    AllianceGenome:WB:WBGene00020839
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of protein stability. Predicted to be active in cytosol and nucleus. Orthologous to human USP13 (ubiquitin specific peptidase 13) and USP5 (ubiquitin specific peptidase 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See usp-5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    14
    Sequence:
    Chromosome: I; NC_003279.8 (6110134..6114549)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Molybdopterin synthase catalytic subunit Neighboring gene Phorbol-ester/DAG-type domain-containing protein Neighboring gene HAP1 N-terminal domain-containing protein Neighboring gene ncRNA

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Ubiquitin carboxyl-terminal hydrolase
    NP_001391078.1
    • Confirmed by transcript evidence
    NP_491765.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6110134..6114549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059364.8NP_491765.2  Ubiquitin carboxyl-terminal hydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491765.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91502
      Conserved Domains (5) summary
      COG5207
      Location:19788
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd02658
      Location:320786
      Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14296
      Location:597634
      UBA1_scUBP14_like; UBA1 domain found in Saccharomyces cerevisiae ubiquitin carboxyl-terminal hydrolase 14 (scUBP14) and similar proteins
      cd14327
      Location:660695
      UBA_atUPL1_2_like; UBA domain found in Arabidopsis thaliana E3 ubiquitin-protein ligase UPL1 (atUPL1), UPL2 (atUPL2) and similar proteins
      pfam02148
      Location:185266
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    2. NM_001404186.1NP_001391078.1  Ubiquitin carboxyl-terminal hydrolase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8D9I6U5