nhr-46 Nuclear Hormone Receptor family [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nhr-46
Official Full Name: Nuclear Hormone Receptor family
Primary source: WormBase:WBGene00003636
Locus tag: CELE_C45E5.6
See related: AllianceGenome:WB:WBGene00003636
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in hypodermis; intestine; muscle cell; neurons; and reproductive system. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nhr-46 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (5747363..5757862, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C45E5.6 (e-PCR)
- UniSTS:308776

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear Hormone Receptor family

NP_001023065.1

Product from WormBase gene class nhr;
Confirmed by transcript evidence

NP_001367663.1

Product from WormBase gene class nhr;
Confirmed by transcript evidence

NP_500858.2

Product from WormBase gene class nhr;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

5747363..5757862 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068457.6 → NP_500858.2 Nuclear Hormone Receptor family [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500858.2

Status: REVIEWED

UniProtKB/TrEMBL

H2KZB8, Q9GTH2

Conserved Domains (2) summary

cd06157
Location:317 → 492

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

smart00399
Location:98 → 167

ZnF_C4; c4 zinc finger in nuclear hormone receptors
NM_001027894.8 → NP_001023065.1 Nuclear Hormone Receptor family [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023065.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95QR2

Conserved Domains (2) summary

cd06157
Location:365 → 540

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

smart00399
Location:146 → 215

ZnF_C4; c4 zinc finger in nuclear hormone receptors
NM_001380240.1 → NP_001367663.1 Nuclear Hormone Receptor family [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q95QR3

Conserved Domains (2) summary

cd06157
Location:184 → 359

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

cl02596
Location:2 → 48

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers