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    nhr-62 NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-62 [ Caenorhabditis elegans ]

    Gene ID: 172836, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhr-62
    Official Full Name
    NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-62
    Primary source
    WormBase:WBGene00003652
    Locus tag
    CELE_Y67A6A.2
    See related
    AllianceGenome:WB:WBGene00003652
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Involved in several processes, including autophagy; regulation of DNA-templated transcription; and triglyceride metabolic process. Predicted to be located in nucleus. Is expressed in several structures, including excretory cell; midbody; neurons; spermatheca; and ventral nerve cord. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhr-62 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (9839598..9844809)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Phospholipase A1 Neighboring gene ncRNA Neighboring gene Non-histone chromosomal protein HMG-14 Neighboring gene Zwei Ig domain protein zig-1 Neighboring gene mRNA stability protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans. Heestand BN, et al. PLoS Genet, 2013. PMID 23935515, Free PMC Article
    2. The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans. Das R, et al. PLoS Genet, 2017 Oct. PMID 29036198, Free PMC Article
    3. Autophagy and Longevity. Nakamura S, et al. Mol Cells, 2018 Jan 31. PMID 29370695, Free PMC Article
    4. H3K9me1/2 methylation limits the lifespan of daf-2 mutants in C. elegans. Huang M, et al. Elife, 2022 Sep 20. PMID 36125117, Free PMC Article
    5. Differential expression of genes in C. elegans reveals transcriptional responses to indirect-acting xenobiotic compounds and insensitivity to 2,3,7,8-tetrachlorodibenzodioxin. Karengera A, et al. Ecotoxicol Environ Saf, 2022 Mar 15. PMID 35219257

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-62
    NP_001129799.1
    • Confirmed by transcript evidence
    NP_001360798.1
    • Confirmed by transcript evidence
    NP_001368765.1
    • Confirmed by transcript evidence
    NP_492607.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9839598..9844809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060206.8 → NP_492607.1  Nuclear hormone receptor family member nhr-62 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492607.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3WFY6, O02279
      UniProtKB/TrEMBL
      Q9GTE5
      Conserved Domains (2) summary
      cd06960
      Location:98 → 173
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      smart00430
      Location:299 → 475
      HOLI; Ligand binding domain of hormone receptors

    2. NM_001373584.2 → NP_001360798.1  Nuclear hormone receptor family member nhr-62 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A565CXP8, Q9GTE5
      Conserved Domains (2) summary
      cd06960
      Location:98 → 173
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      smart00430
      Location:299 → 472
      HOLI; Ligand binding domain of hormone receptors

    3. NM_001136327.4 → NP_001129799.1  Nuclear hormone receptor family member nhr-62 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129799.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02279
      Conserved Domains (1) summary
      smart00430
      Location:137 → 313
      HOLI; Ligand binding domain of hormone receptors

    4. NM_001381160.1 → NP_001368765.1  NR LBD domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A565CXN2
      Conserved Domains (1) summary
      smart00430
      Location:137 → 310
      HOLI; Ligand binding domain of hormone receptors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02279.3

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