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    inos-1 inositol-3-phosphate synthase [ Caenorhabditis elegans ]

    Gene ID: 174792, updated on 9-Dec-2024

    Summary

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    Official Symbol
    inos-1
    Official Full Name
    inositol-3-phosphate synthase
    Primary source
    WormBase:WBGene00012148
    Locus tag
    CELE_VF13D12L.1
    See related
    AllianceGenome:WB:WBGene00012148
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable inositol-3-phosphate synthase activity. Predicted to be involved in inositol biosynthetic process. Predicted to be active in cytoplasm. Is expressed in germ line. Orthologous to human ISYNA1 (inositol-3-phosphate synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See inos-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003280.10 (11698317..11700300, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene CUB domain-containing protein Neighboring gene BTB domain-containing protein Neighboring gene Threonine--tRNA ligase, cytoplasmic;threonine--tRNA ligase Neighboring gene ERCC4 domain-containing protein Neighboring gene ncRNA Neighboring gene Malate dehydrogenase Neighboring gene Cyclopropane-fatty-acyl-phospholipid synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mood stabilizer valproate inhibits both inositol- and diacylglycerol-signaling pathways in Caenorhabditis elegans. Tokuoka SM, et al. Mol Biol Cell, 2008 May. PMID 18287529, Free PMC Article
    2. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables inositol-3-phosphate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol-3-phosphate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inositol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    inositol-3-phosphate synthase
    NP_496499.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11698317..11700300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064098.6 → NP_496499.2  inositol-3-phosphate synthase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496499.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED01
      Conserved Domains (1) summary
      pfam07994
      Location:78 → 494
      NAD_binding_5; Myo-inositol-1-phosphate synthase
    Nucleotide Protein
    Heading Accession and Version

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