nhr-42 Nuclear hormone receptor family member nhr-42 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nhr-42
Official Full Name: Nuclear hormone receptor family member nhr-42
Primary source: WormBase:WBGene00003632
Locus tag: CELE_C33G8.6
See related: AllianceGenome:WB:WBGene00003632
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in head; hypodermis; intestine; and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nhr-42 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 7

Sequence:: Chromosome: V; NC_003283.11 (6998819..7000651)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C. elegans orphan nuclear receptor NHR-42 represses innate immunity and promotes lipid loss downstream of HLH-30/TFEB.
Title: C. elegans orphan nuclear receptor NHR-42 represses innate immunity and promotes lipid loss downstream of HLH-30/TFEB.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C33G8.6 (e-PCR)
- UniSTS:309228

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear hormone receptor family member nhr-42

NP_504771.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

6998819..7000651

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072370.4 → NP_504771.1 Nuclear hormone receptor family member nhr-42 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504771.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76828

UniProtKB/TrEMBL

Q9GTH5

Conserved Domains (2) summary

smart00399
Location:9 → 78

ZnF_C4; c4 zinc finger in nuclear hormone receptors

smart00430
Location:151 → 327

HOLI; Ligand binding domain of hormone receptors