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    vha-6 V-type proton ATPase 116 kDa subunit a 3 [ Caenorhabditis elegans ]

    Gene ID: 174743, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vha-6
    Official Full Name
    V-type proton ATPase 116 kDa subunit a 3
    Primary source
    WormBase:WBGene00006915
    Locus tag
    CELE_VW02B12L.1
    See related
    AllianceGenome:WB:WBGene00006915
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase binding activity. Involved in nematode larval development. Located in apical plasma membrane. Part of vacuolar proton-transporting V-type ATPase complex. Is expressed in several structures, including Psub2; excretory cell; intestine; pharyngeal-intestinal valve; and uterus. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; developmental and epileptic encephalopathy 104; renal tubular acidosis; and wrinkly skin syndrome. Orthologous to several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1); ATP6V0A2 (ATPase H+ transporting V0 subunit a2); and ATP6V0A4 (ATPase H+ transporting V0 subunit a4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vha-6 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (11435210..11438452, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene EGF-like domain-containing protein Neighboring gene Coiled-coil domain-containing protein 172 Neighboring gene Kinesin motor domain-containing protein Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene tRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A vacuolar-type proton (H+) translocating ATPase alpha subunit encoded by the Hc-vha-6 gene of Haemonchus contortus. Hu M, et al. Mol Cell Probes, 2010 Aug. PMID 20362051
    2. Loss of the apical V-ATPase a-subunit VHA-6 prevents acidification of the intestinal lumen during a rhythmic behavior in C. elegans. Allman E, et al. Am J Physiol Cell Physiol, 2009 Nov. PMID 19741196, Free PMC Article
    3. Nanoluciferase-Based Method for Detecting Gene Expression in Caenorhabditis elegans. Sfarcic I, et al. Genetics, 2019 Dec. PMID 31585955, Free PMC Article
    4. Somatic expression of unc-54 and vha-6 mRNAs declines but not pan-neuronal rgef-1 and unc-119 expression in aging Caenorhabditis elegans. Adamla F, et al. Sci Rep, 2015 Jun 2. PMID 26031360, Free PMC Article
    5. Four subunit a isoforms of Caenorhabditis elegans vacuolar H+-ATPase. Cell-specific expression during development. Oka T, et al. J Biol Chem, 2001 Aug 31. PMID 11441002

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VHA-6 is essential for proton pumping following defecation
      Title: Loss of the apical V-ATPase a-subunit VHA-6 prevents acidification of the intestinal lumen during a rhythmic behavior in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar acidification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of vacuolar proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    V-type proton ATPase 116 kDa subunit a 3
    NP_496436.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11435210..11438452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064035.9 → NP_496436.1  V-type proton ATPase 116 kDa subunit a 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496436.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGP4
      Conserved Domains (2) summary
      COG1269
      Location:28 → 858
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:28 → 853
      V_ATPase_I; V-type ATPase 116kDa subunit family
    Nucleotide Protein
    Heading Accession and Version

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