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    hacl-1 2-hydroxyacyl-CoA lyase [ Caenorhabditis elegans ]

    Gene ID: 174758, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hacl-1
    Official Full Name
    2-hydroxyacyl-CoA lyase
    Primary source
    WormBase:WBGene00007143
    Locus tag
    CELE_B0334.3
    See related
    AllianceGenome:WB:WBGene00007143
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable thiamine pyrophosphate binding activity. Predicted to be involved in fatty acid alpha-oxidation. Predicted to be active in peroxisome. Orthologous to human HACL1 (2-hydroxyacyl-CoA lyase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hacl-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (11489607..11492963, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Potassium channel domain-containing protein Neighboring gene ncRNA Neighboring gene Transthyretin-like family protein Neighboring gene FMRF-Like Peptide Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Chloride channel CLIC-like protein 1 Neighboring gene PRELI/MSF1 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative metabolomics with Metaboseek reveals functions of a conserved fat metabolism pathway in C. elegans. Helf MJ, et al. Nat Commun, 2022 Feb 10. PMID 35145075, Free PMC Article
    2. A UPR-independent infection-specific role for a BiP/GRP78 protein in the control of antimicrobial peptide expression in C. elegans epidermis. Couillault C, et al. Virulence, 2012 May 1. PMID 22546897, Free PMC Article
    3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine pyrophosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiamine pyrophosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid alpha-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    2-hydroxyacyl-CoA lyase
    NP_001379093.1
    • Confirmed by transcript evidence
    NP_496454.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11489607..11492963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064053.6 → NP_496454.1  2-hydroxyacyl-CoA lyase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496454.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17474
      Conserved Domains (4) summary
      PRK09259
      Location:68 → 615
      PRK09259; putative oxalyl-CoA decarboxylase; Validated
      cd02004
      Location:434 → 616
      TPP_BZL_OCoD_HPCL; Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL ...
      pfam00205
      Location:261 → 391
      TPP_enzyme_M; Thiamine pyrophosphate enzyme, central domain
      pfam02776
      Location:74 → 240
      TPP_enzyme_N; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain

    2. NM_001393195.1 → NP_001379093.1  2-hydroxyacyl-CoA lyase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17475
      Conserved Domains (1) summary
      PRK09259
      Location:2 → 544
      PRK09259; putative oxalyl-CoA decarboxylase; Validated
    Nucleotide Protein
    Heading Accession and Version

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