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    cdr-4 CaDmium Responsive [ Caenorhabditis elegans ]

    Gene ID: 259654, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdr-4
    Official Full Name
    CaDmium Responsive
    Primary source
    WormBase:WBGene00010470
    Locus tag
    CELE_K01D12.11
    See related
    AllianceGenome:WB:WBGene00010470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in stress response to cadmium ion. Acts upstream of or within IRE1-mediated unfolded protein response. Located in lysosome. Is expressed in intestine and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cdr-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (12407366..12408625, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene Cement protein Neighboring gene GST C-terminal domain-containing protein Neighboring gene CaDmium Responsive

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of two homologs of the Caenorhabditis elegans cadmium-responsive gene cdr-1: cdr-4 and cdr-6. Dong J, et al. J Mol Biol, 2008 Feb 22. PMID 18177893, Free PMC Article
    2. Identification and characterization of a family of Caenorhabditis elegans genes that is homologous to the cadmium-responsive gene cdr-1. Dong J, et al. Biochim Biophys Acta, 2005 Jan 21. PMID 15652154
    3. Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure. Boyd WA, et al. Mutat Res, 2010 Jan 5. PMID 19879883, Free PMC Article
    4. A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response. Urano F, et al. J Cell Biol, 2002 Aug 19. PMID 12186849, Free PMC Article
    5. Development of a transcription-based bioanalytical tool to quantify the toxic potencies of hydrophilic compounds in water using the nematode Caenorhabditis elegans. Karengera A, et al. Ecotoxicol Environ Saf, 2021 Dec 20. PMID 34700171

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    acts_upstream_of_or_within IRE1-mediated unfolded protein response HEP PubMed 
    involved_in endoplasmic reticulum unfolded protein response HEP PubMed 
    involved_in innate immune response HEP PubMed 
    involved_in stress response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CaDmium Responsive
    NP_506110.1
    • Product from WormBase gene class cdr;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12407366..12408625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073709.7 → NP_506110.1  CaDmium Responsive [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506110.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDZ7
      Conserved Domains (3) summary
      cd03193
      Location:200 → 267
      GST_C_Metaxin; C-terminal, alpha helical domain of Metaxin and related proteins
      COG0625
      Location:59 → 267
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03080
      Location:46 → 118
      GST_N_Metaxin_like; GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It ...
    Nucleotide Protein
    Heading Accession and Version

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