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    folt-1 Folate transporter 1 [ Caenorhabditis elegans ]

    Gene ID: 179544, updated on 9-Dec-2024

    Summary

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    Official Symbol
    folt-1
    Official Full Name
    Folate transporter 1
    Primary source
    WormBase:WBGene00007388
    Locus tag
    CELE_C06H2.4
    See related
    AllianceGenome:WB:WBGene00007388
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable folic acid binding activity and vitamin transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including body wall musculature; intestine; pharynx; reproductive system; and tail. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; biotin-responsive basal ganglia disease; cleft lip; dextro-looped transposition of the great arteries; and megaloblastic anemia. Orthologous to several human genes including SLC19A3 (solute carrier family 19 member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See folt-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (11141479..11143121)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene GLOBIN domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F-box domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Neuropeptide-like protein 33

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Knockout of the folate transporter folt-1 causes germline and somatic defects in C. elegans. Austin MU, et al. BMC Dev Biol, 2010 May 4. PMID 20441590, Free PMC Article
    2. Cloning and functional characterization of a folate transporter from the nematode Caenorhabditis elegans. Balamurugan K, et al. Am J Physiol Cell Physiol, 2007 Aug. PMID 17475669
    3. Folate receptor overexpression induces toxicity in a diet-dependent manner in C. elegans. Shrestha B, et al. Sci Rep, 2024 Jan 11. PMID 38212621, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables folic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables vitamin transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vitamin transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vitamin transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Folate transporter 1
    NP_505833.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11141479..11143121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073432.5 → NP_505833.3  Folate transporter 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505833.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A3FMP6, Q17766
      Conserved Domains (1) summary
      pfam01770
      Location:2 → 403
      Folate_carrier; Reduced folate carrier
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17766.3

    Gene LinkOut

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