atp-2 ATP synthase subunit beta, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: atp-2
Official Full Name: ATP synthase subunit beta, mitochondrial
Primary source: WormBase:WBGene00000229
Locus tag: CELE_C34E10.6
See related: AllianceGenome:WB:WBGene00000229
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein domain specific binding activity. Involved in several processes, including determination of adult lifespan; inductive cell migration; and nematode pharyngeal pumping. Located in mitochondrion and non-motile cilium. Is expressed in several structures, including enteric muscle; excretory cell; intestine; nervous system; and reproductive system. Orthologous to human ATP5F1B (ATP synthase F1 subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See atp-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (5228417..5230536)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

atp-2 is involved in the production or the regulation of a global, developmental signal required for the L3-to-L4 transition.
Title: Mitochondrial ATP synthase controls larval development cell nonautonomously in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C34E10.6 (e-PCR)
- UniSTS:309247

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATP synthase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ATP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ATP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in behavior	IEA Inferred from Electronic Annotation more info
involved_in dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defecation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inductive cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton motive force-driven ATP synthesis	IEA Inferred from Electronic Annotation more info
involved_in proton motive force-driven mitochondrial ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
part_of proton-transporting ATP synthase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proton-transporting ATP synthase complex, catalytic core F(1)	IBA Inferred from Biological aspect of Ancestor more info
part_of proton-transporting ATP synthase complex, catalytic core F(1)	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP synthase subunit beta, mitochondrial

NP_498111.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5228417..5230536

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065710.8 → NP_498111.2 ATP synthase subunit beta, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498111.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P46561

Conserved Domains (4) summary

PRK09280
Location:67 → 533

PRK09280; F0F1 ATP synthase subunit beta; Validated

cd01133
Location:140 → 419

F1-ATPase_beta; F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a ...

pfam00306
Location:427 → 535

ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain

pfam02874
Location:72 → 138

ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain