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    vps-13A Vacuolar protein sorting-associated protein 13 [ Caenorhabditis elegans ]

    Gene ID: 172705, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vps-13A
    Official Full Name
    Vacuolar protein sorting-associated protein 13
    Primary source
    WormBase:WBGene00011629
    Locus tag
    CELE_T08G11.1
    See related
    AllianceGenome:WB:WBGene00011629
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in protein retention in Golgi apparatus and protein targeting to vacuole. Is expressed in body wall musculature; hypodermis; and reproductive system. Human ortholog(s) of this gene implicated in Parkinson's disease 23; choreaacanthocytosis; and choreatic disease. Orthologous to several human genes including VPS13A (vacuolar protein sorting 13 homolog A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vps-13A in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    22
    Sequence:
    Chromosome: I; NC_003279.8 (8905648..8916805, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Trimethylguanosine synthase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SH2 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
    2. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    Vacuolar protein sorting-associated protein 13
    NP_740899.1
    • Confirmed by transcript evidence
    NP_740900.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8905648..8916805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170907.7 → NP_740899.1  Vacuolar protein sorting-associated protein 13 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740899.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3D2
      Conserved Domains (6) summary
      COG5043
      Location:4 → 2154
      MRS6; Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion]
      pfam06650
      Location:2224 → 2463
      SHR-BD; SHR-binding domain of vacuolar-sorting associated protein 13
      pfam12624
      Location:4 → 113
      Chorein_N; N-terminal region of Chorein or VPS13
      pfam16908
      Location:139 → 373
      VPS13; Vacuolar sorting-associated protein 13, N-terminal
      pfam16909
      Location:2776 → 2955
      VPS13_C; Vacuolar-sorting-associated 13 protein C-terminal
      pfam16910
      Location:560 → 780
      VPS13_mid_rpt; Repeating coiled region of VPS13

    2. NM_171842.5 → NP_740900.1  Vacuolar protein sorting-associated protein 13 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740900.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q94010
      Conserved Domains (6) summary
      COG5043
      Location:4 → 2154
      MRS6; Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion]
      pfam06650
      Location:2224 → 2490
      SHR-BD; SHR-binding domain of vacuolar-sorting associated protein 13
      pfam12624
      Location:4 → 113
      Chorein_N; N-terminal region of Chorein or VPS13
      pfam16908
      Location:139 → 373
      VPS13; Vacuolar sorting-associated protein 13, N-terminal
      pfam16909
      Location:2803 → 2982
      VPS13_C; Vacuolar-sorting-associated 13 protein C-terminal
      pfam16910
      Location:560 → 780
      VPS13_mid_rpt; Repeating coiled region of VPS13
    Nucleotide Protein
    Heading Accession and Version

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