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    cyc-1 Cytochrome c domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172582, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cyc-1
    Official Full Name
    Cytochrome c domain-containing protein
    Primary source
    WormBase:WBGene00000869
    Locus tag
    CELE_C54G4.8
    See related
    AllianceGenome:WB:WBGene00000869
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable electron transfer activity; heme binding activity; and metal ion binding activity. Involved in determination of adult lifespan and proton motive force-driven mitochondrial ATP synthesis. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex III. Is expressed in several structures, including germ line. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 6. Orthologous to human CYC1 (cytochrome c1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cyc-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (8022674..8024422, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Putative ribosomal protein S6 kinase alpha-2;Ribosomal protein S6 kinase Neighboring gene AB hydrolase-1 domain-containing protein Neighboring gene Nucleotide PPase Neighboring gene RAP domain-containing protein Neighboring gene Eukaryotic translation initiation factor 2 subunit 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bridging the phenotypic gap: real-time assessment of mitochondrial function and metabolism of the nematode Caenorhabditis elegans. Lagido C, et al. BMC Physiol, 2008 Apr 2. PMID 18384668, Free PMC Article
    2. The cyclin-dependent kinase inhibitors, cki-1 and cki-2, act in overlapping but distinct pathways to control cell cycle quiescence during C. elegans development. Buck SH, et al. Cell Cycle, 2009 Aug 15. PMID 19597327, Free PMC Article
    3. Rates of behavior and aging specified by mitochondrial function during development. Dillin A, et al. Science, 2002 Dec 20. PMID 12471266
    4. TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Robida-Stubbs S, et al. Cell Metab, 2012 May 2. PMID 22560223, Free PMC Article
    5. Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. Rea SL, et al. PLoS Biol, 2007 Oct 2. PMID 17914900, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cytochrome c domain-containing protein
    NP_492207.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8022674..8024422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059806.7 → NP_492207.1  Cytochrome c domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492207.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18853
      Conserved Domains (1) summary
      pfam02167
      Location:49 → 264
      Cytochrom_C1; Cytochrome C1 family
    Nucleotide Protein
    Heading Accession and Version

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