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    ctsa-3.2 Serine carboxypeptidase ctsa-3.2 [ Caenorhabditis elegans ]

    Gene ID: 182429, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ctsa-3.2
    Official Full Name
    Serine carboxypeptidase ctsa-3.2
    Primary source
    WormBase:WBGene00007462
    Locus tag
    CELE_C08H9.1
    See related
    AllianceGenome:WB:WBGene00007462
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type carboxypeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in galactosialidosis and lysosomal storage disease. Orthologous to human CTSA (cathepsin A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ctsa-3.2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    12
    Sequence:
    Chromosome: II; NC_003280.10 (9875179..9877887)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene GH18 domain-containing protein Neighboring gene GH18 domain-containing protein Neighboring gene ncRNA Neighboring gene Transmembrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lysosomal chloride transporter CLH-6 protects lysosome membrane integrity via cathepsin activation. Zhang Q, et al. J Cell Biol, 2023 Jun 5. PMID 37058288, Free PMC Article
    2. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serine carboxypeptidase ctsa-3.2
    NP_001364589.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9875179..9877887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377839.2 → NP_001364589.1  Serine carboxypeptidase ctsa-3.2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P52714
      Conserved Domains (1) summary
      pfam00450
      Location:27 → 505
      Peptidase_S10; Serine carboxypeptidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52714.2

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