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    klp-17 Kinesin motor domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174750, updated on 9-Dec-2024

    Summary

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    Official Symbol
    klp-17
    Official Full Name
    Kinesin motor domain-containing protein
    Primary source
    WormBase:WBGene00002227
    Locus tag
    CELE_W02B12.7
    See related
    AllianceGenome:WB:WBGene00002227
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable microtubule binding activity. Involved in chromosome segregation. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in microtubule cytoskeleton. Is expressed in germ line and sperm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See klp-17 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (11465940..11467641, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene putative splicing factor, arginine/serine-rich 1 Neighboring gene pseudo Neighboring gene Alanine--tRNA ligase, mitochondrial Neighboring gene Rho GTPase-activating protein 68F;Rho-GAP domain-containing protein Neighboring gene CDGSH iron-sulfur domain-containing protein 2 homologue;Iron-binding zinc finger CDGSH type domain-containing protein Neighboring gene Mitoferrin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Essential kinesins: characterization of Caenorhabditis elegans KLP-15. Robin G, et al. Biochemistry, 2005 May 3. PMID 15850386
    2. Structure and biological evaluation of Caenorhabditis elegans CISD-1/mitoNEET, a KLP-17 tail domain homologue, supports attenuation of paraquat-induced oxidative stress through a p38 MAPK-mediated antioxidant defense response. Boos JR, et al. Adv Redox Res, 2022 Dec. PMID 36533211, Free PMC Article
    3. A novel C-terminal kinesin subfamily may be involved in chromosomal movement in caenorhabditis elegans. Ali MY, et al. FEBS Lett, 2000 Mar 17. PMID 10722848
    4. cDNA cloning and expression of a C-terminus motor kinesin-like protein KLP-17, involved in chromosomal movement in Caenorhabditis elegans. Ali MY, et al. Biochem Biophys Res Commun, 2000 Jan 19. PMID 10631116
    5. Metazoan motor models: kinesin superfamily in C. elegans. Siddiqui SS. Traffic, 2002 Jan. PMID 11872139

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule-based process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Kinesin motor domain-containing protein
    NP_496446.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11465940..11467641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064045.6 → NP_496446.3  Kinesin motor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496446.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23124
      Conserved Domains (3) summary
      PRK03992
      Location:70 → 116
      PRK03992; proteasome-activating nucleotidase; Provisional
      smart00129
      Location:145 → 464
      KISc; Kinesin motor, catalytic domain. ATPase
      TIGR04523
      Location:11 → 146
      Mplasa_alph_rch; helix-rich Mycoplasma protein
    Nucleotide Protein
    Heading Accession and Version

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