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    dmd-10 Doublesex- and mab-3-related transcription factor dmd-10 [ Caenorhabditis elegans ]

    Gene ID: 183202, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dmd-10
    Official Full Name
    Doublesex- and mab-3-related transcription factor dmd-10
    Primary source
    WormBase:WBGene00007929
    Locus tag
    CELE_C34D1.1
    See related
    AllianceGenome:WB:WBGene00007929
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including male anatomical structure morphogenesis; mechanosensory behavior; and negative regulation of synapse pruning. Predicted to be active in nucleus. Is expressed in several structures, including AVG; body wall musculature; head neurons; intestine; and vulval muscle. Orthologous to human DMRTC2 (DMRT like family C2) and DMRT1 (doublesex and mab-3 related transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dmd-10 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (13222116..13236607, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DMD-10 is dispensable for the initial development of amphid sensory neurons and their survival in mature C. elegans. Nguyen I, et al. MicroPubl Biol, 2021 Jun 14. PMID 34142022, Free PMC Article
    2. The Doublesex/Mab-3 domain transcription factor DMD-10 regulates ASH-dependent behavioral responses. Durbeck J, et al. PeerJ, 2021. PMID 33665029, Free PMC Article
    3. Sex-specific pruning of neuronal synapses in Caenorhabditis elegans. Oren-Suissa M, et al. Nature, 2016 May 12. PMID 27144354, Free PMC Article
    4. Characterization of the Doublesex/MAB-3 transcription factor DMD-9 in Caenorhabditis elegans. Godini R, et al. G3 (Bethesda), 2023 Feb 9. PMID 36454093, Free PMC Article
    5. A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans. Updike DL, et al. Genetics, 2009 Dec. PMID 19805813, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in male anatomical structure morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of synapse pruning IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sex differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Doublesex- and mab-3-related transcription factor dmd-10
    NP_001379162.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13222116..13236607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392638.1 → NP_001379162.1  Doublesex- and mab-3-related transcription factor dmd-10 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEJ1
      Conserved Domains (1) summary
      smart00301
      Location:115 → 168
      DM; Doublesex DNA-binding motif
    Nucleotide Protein
    Heading Accession and Version

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