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    oct-2 Major facilitator superfamily (MFS) profile domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181325, updated on 9-Dec-2024

    Summary

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    Official Symbol
    oct-2
    Official Full Name
    Major facilitator superfamily (MFS) profile domain-containing protein
    Primary source
    WormBase:WBGene00003843
    Locus tag
    CELE_ZK455.8
    See related
    AllianceGenome:WB:WBGene00003843
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Orthologous to human SLC22A15 (solute carrier family 22 member 15). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See oct-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    13
    Sequence:
    Chromosome: X; NC_003284.9 (11346455..11350247)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Receptor-type guanylate cyclase gcy-9 Neighboring gene ncRNA Neighboring gene Cytoplasmic aconitate hydratase Neighboring gene Multidrug resistance protein pgp-3 Neighboring gene P-GlycoProtein related

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel approach using C. elegans DNA damage-induced apoptosis to characterize the dynamics of uptake transporters for therapeutic drug discoveries. Papaluca A, et al. Sci Rep, 2016 Oct 27. PMID 27786254, Free PMC Article
    2. Knockout of a putative ergothioneine transporter in Caenorhabditis elegans decreases lifespan and increases susceptibility to oxidative damage. Cheah IK, et al. Free Radic Res, 2013 Dec. PMID 24074059
    3. Acetylcholine. Rand JB. WormBook, 2007 Jan 30. PMID 18050502, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Major facilitator superfamily (MFS) profile domain-containing protein
    NP_001024992.2
    • Confirmed by transcript evidence
    NP_509899.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      11346455..11350247
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077498.9 → NP_509899.3  Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509899.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23501
      Conserved Domains (1) summary
      cd17317
      Location:281 → 673
      MFS_SLC22; Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily

    2. NM_001029821.6 → NP_001024992.2  Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024992.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE82
      Conserved Domains (2) summary
      PRK10077
      Location:144 → 174
      xylE; D-xylose transporter XylE; Provisional
      cd17317
      Location:1 → 385
      MFS_SLC22; Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version

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