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    pks-1 oleoyl-[acyl-carrier-protein] hydrolase [ Caenorhabditis elegans ]

    Gene ID: 180815, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pks-1
    Official Full Name
    oleoyl-[acyl-carrier-protein] hydrolase
    Primary source
    WormBase:WBGene00016558
    Locus tag
    CELE_C41A3.1
    See related
    AllianceGenome:WB:WBGene00016558
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fatty acid synthase activity. Predicted to be involved in fatty acid biosynthetic process. Is expressed in CANL and CANR. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pks-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    31
    Sequence:
    Chromosome: X; NC_003284.9 (5413810..5441961)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene tRNA-Met Neighboring gene Coiled-coil domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan. Feng L, et al. Nat Commun, 2021 Aug 13. PMID 34389721, Free PMC Article
    2. A hybrid polyketide-nonribosomal peptide in nematodes that promotes larval survival. Shou Q, et al. Nat Chem Biol, 2016 Oct. PMID 27501395, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan.
      Title: Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acyl-[ACP] hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopantetheine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small molecule biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in toxin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    oleoyl-[acyl-carrier-protein] hydrolase
    NP_001317900.1
    • Confirmed by transcript evidence
    NP_508923.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5413810..5441961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001330898.4 → NP_001317900.1  oleoyl-[acyl-carrier-protein] hydrolase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1C3NSM6

    2. NM_076522.3 → NP_508923.2  oleoyl-[acyl-carrier-protein] hydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508923.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18559
      Conserved Domains (16) summary
      PRK14691
      Location:4335 → 4629
      PRK14691; 3-oxoacyl-(acyl carrier protein) synthase II; Provisional
      smart00822
      Location:3203 → 3377
      PKS_KR; This enzymatic domain is part of bacterial polyketide synthases
      smart00823
      Location:2943 → 3024
      PKS_PP; Phosphopantetheine attachment site
      smart00825
      Location:1891 → 2282
      PKS_KS; Beta-ketoacyl synthase
      smart00827
      Location:3649 → 3927
      PKS_AT; Acyl transferase domain in polyketide synthase (PKS) enzymes
      COG3321
      Location:3609 → 3984
      PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
      cd00833
      Location:5258 → 5645
      PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
      TIGR01733
      Location:7000 → 7356
      AA-adenyl-dom; amino acid adenylation domain
      pfam00550
      Location:6476 → 6539
      PP-binding; Phosphopantetheine attachment site
      pfam16197
      Location:376 → 433
      KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
      cl00509
      Location:1544 → 1759
      hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
      cl08282
      Location:5761 → 6023
      Acyl_transf_1; Acyl transferase domain
      cl17068
      Location:6990 → 7412
      AFD_class_I; Adenylate forming domain, Class I superfamily
      cl21454
      Location:4991 → 5131
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
      cl21494
      Location:7527 → 7622
      Abhydrolase; alpha/beta hydrolases
      cl23853
      Location:6558 → 6831
      Condensation; Condensation domain
    Nucleotide Protein
    Heading Accession and Version

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