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    col-49 Cuticle collagen 49 [ Caenorhabditis elegans ]

    Gene ID: 187239, updated on 9-Dec-2024

    Summary

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    Official Symbol
    col-49
    Official Full Name
    Cuticle collagen 49
    Primary source
    WormBase:WBGene00000626
    Locus tag
    CELE_K09H9.3
    See related
    AllianceGenome:WB:WBGene00000626
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of cuticle. Involved in collagen and cuticulin-based cuticle development. Is expressed in hyp7 syncytium and seam cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See col-49 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003279.8 (3137185..3138447)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene DUF19 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of C. elegans L4 cuticle collagen genes by the heterochronic protein LIN-29. Abete-Luzi P, et al. Genesis, 2018 May. PMID 29604168, Free PMC Article
    2. Use of an activated beta-catenin to identify Wnt pathway target genes in caenorhabditis elegans, including a subset of collagen genes expressed in late larval development. Jackson BM, et al. G3 (Bethesda), 2014 Apr 16. PMID 24569038, Free PMC Article
    3. The adhesion GPCR and PCP component flamingo (FMI-1) alters body size and regulates the composition of the extracellular matrix. Schön JL, et al. Matrix Biol, 2024 Apr. PMID 38378098
    4. New Roles for the Heterochronic Transcription Factor LIN-29 in Cuticle Maintenance and Lipid Metabolism at the Larval-to-Adult Transition in Caenorhabditis elegans. Abete-Luzi P, et al. Genetics, 2020 Mar. PMID 31974205, Free PMC Article
    5. Identification of innate immunity genes and pathways using a comparative genomics approach. Alper S, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18463287, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of cuticle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen and cuticulin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cuticle collagen 49
    NP_491106.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3137185..3138447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058705.5 → NP_491106.1  Cuticle collagen 49 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491106.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44989
      Conserved Domains (2) summary
      pfam01391
      Location:186 → 243
      Collagen; Collagen triple helix repeat (20 copies)
      smart01088
      Location:4 → 56
      Col_cuticle_N; Nematode cuticle collagen N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O44989.1

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